GLYX-13 PREPARATION METHOD AND INTERMEDIATE COMPONENT THEREOF

Title:

GLYX-13 PREPARATION METHOD AND INTERMEDIATE COMPONENT THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/210336

Kind Code:

A1

Abstract:

A GLYX-13 preparation method and an intermediate compound thereof. According to the provided method, Fmoc-O-tert-butyl-L-threonine, Fmoc-L-proline, N-carboxybenzyl-L-threonine amide, and proline benzyl ester hydrochloride are used as starting materials; in virtue of eight easy-to-operate and economical synthetic steps, GLYX-13 can be prepared on a commercial scale and with a high yield, without using any expensive peptide condensation agent or any controlled precursor or aggressive deprotection agent.

Inventors:

LIU JINGJIAN (CN)
ZHANG LIANGREN (CN)
ZHANG GUISEN (CN)
WANG GUOHAI (CN)

Application Number:

PCT/CN2018/087487

Publication Date:

November 22, 2018

Filing Date:

May 18, 2018

Export Citation:

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Assignee:

NHWA PHARMA CORP (CN)
UNIV BEIJING (CN)

International Classes:

A61K38/07; C07K5/103; A61P25/24; C07K1/06

Domestic Patent References:

WO2016014982A1	2016-01-28
WO2013063120A2	2013-05-02

Foreign References:

CN107474107A	2017-12-15
CN104109189A	2014-10-22

Attorney, Agent or Firm:

NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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