Title:
GOLD-IN-SILICON NANOASSEMBLY FOR THERMAL THERAPY AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2013/095736
Kind Code:
A3
Abstract:
Disclosed are methods and compositions for nanotechnology-based therapy of mammalian diseases. Also disclosed is a gold-in-porous silicon nanoassembly that is effective in the targeted, localized, treatment of human hyperproliferative disorders, including, for example, cancer of the breast. Using systemic administration of the nanoassembly vector, direct thermal ablative therapy is facilitate upon localized application of near-infrared energy to the target site, wherein the gold nanoparticles release heat to destroy the cancer tissue.
Inventors:
SHEN HAIFA (US)
FERRARI MAURO (US)
LI CHUN (US)
YOU JIAN (CN)
FERRARI MAURO (US)
LI CHUN (US)
YOU JIAN (CN)
Application Number:
PCT/US2012/057365
Publication Date:
January 23, 2014
Filing Date:
September 26, 2012
Export Citation:
Assignee:
METHODIST HOSPITAL RES INST (US)
SHEN HAIFA (US)
FERRARI MAURO (US)
LI CHUN (US)
YOU JIAN (CN)
SHEN HAIFA (US)
FERRARI MAURO (US)
LI CHUN (US)
YOU JIAN (CN)
International Classes:
A61K41/00; A61P35/00
Domestic Patent References:
| WO2009097439A1 | 2009-08-06 |
Foreign References:
| US20090252811A1 | 2009-10-08 |
Other References:
HU M ET AL: "Heat dissipation in gold-silica core-shell nanoparticles", CHEMICAL PHYSICS LETTERS, ELSEVIER BV, NL, vol. 372, no. 5-6, 6 May 2003 (2003-05-06), pages 767 - 772, XP027472876, ISSN: 0009-2614, [retrieved on 20030506], DOI: 10.1016/S0009-2614(03)00506-2
TASCIOTTI ENNIO ET AL: "Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications", NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 3, no. 3, 1 March 2008 (2008-03-01), pages 151 - 157, XP002528093, ISSN: 1748-3395, DOI: 10.1038/NNANO.2008.34
CHANSEOK HONG ET AL: "Porous silicon nanoparticles for cancer photothermotherapy", 2 June 2011 (2011-06-02), XP055084804, Retrieved from the Internet [retrieved on 20131022]
TASCIOTTI ENNIO ET AL: "Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications", NATURE NANOTECHNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 3, no. 3, 1 March 2008 (2008-03-01), pages 151 - 157, XP002528093, ISSN: 1748-3395, DOI: 10.1038/NNANO.2008.34
CHANSEOK HONG ET AL: "Porous silicon nanoparticles for cancer photothermotherapy", 2 June 2011 (2011-06-02), XP055084804, Retrieved from the Internet
Attorney, Agent or Firm:
MOORE, Mark et al. (LLP2323 Victory Avenue, Suite 70, Dallas Texas, US)
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