Title:
GPC3 EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2016/092787
Kind Code:
A1
Abstract:
Isolated GPC3-derived epitope peptides having Th1 cell inducibility are disclosed herein. Such peptides can be recognized by MHC class II molecules and induce Th1 cells. In preferred embodiments, such a peptide of the present invention can promiscuously bind to MHC class II molecules and induce GPC3-specific cytotoxic T lymphocytes (CTLs) in addition to Th1 cells. Such peptides are thus suitable for use in enhancing immune response in a subject, and accordingly find use in cancer immunotherapy, in particular, as cancer vaccines. Also disclosed herein are polynucleotides that encode any of the aforementioned peptides, APCs and Th1 cells induced by such peptides and methods of induction associated therewith. Pharmaceutical compositions that comprise any of the aforementioned components as active ingredients find use in the treatment and/or prevention of cancers or tumors including, for example, hepatocellular carcinoma and melanoma.
Inventors:
NISHIMURA YASUHARU (JP)
TOMITA YUSUKE (JP)
OSAWA RYUJI (JP)
TOMITA YUSUKE (JP)
OSAWA RYUJI (JP)
Application Number:
PCT/JP2015/006029
Publication Date:
June 16, 2016
Filing Date:
December 04, 2015
Export Citation:
Assignee:
ONCOTHERAPY SCIENCE INC (JP)
International Classes:
C07K7/06; A61K31/7088; A61K48/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/68; G01N33/50; G01N33/68
Domestic Patent References:
| WO2009069302A1 | 2009-06-04 | |||
| WO2008126413A1 | 2008-10-23 | |||
| WO2011125334A1 | 2011-10-13 | |||
| WO2014097648A1 | 2014-06-26 | |||
| WO2004018667A1 | 2004-03-04 |
Other References:
SAWADA Y. ET AL.: "Phase I trial of a glypican-3-derived peptide vaccine for advanced hepatocellular carcinoma: immunologic evidence and potential for improving overall survival.", CLINICAL CANCER RESEARCH, vol. 18, no. 13, 2012, pages 3686 - 3696, XP055425261
See also references of EP 3230301A4
See also references of EP 3230301A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)
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