GPR119 AGONIST

WIPO Patent Application WO/2012/117996

A1

A compound represented by general formula (I), said compound being a GPR119 agonist, or a salt thereof which is usable as an antidiabetic drug. In general formula (I): one of T1, T2, T3 and T4 represents N and the remainder three represent CR5, or T1, T2, T3 and T4 all represent CR5; R5 represents H, a halogen atom, a C1-8 alkyl group, a C1-8 alkylsulfonyl group, a 5- or 6-membered heteroaryl group or the like; R3 and R4 represent H or a C1-8 alkyl group; --- represents a single or double bond; A represents (CH2)m or the like; X and Y represent an optionally substituted C1-3 alkylene group; Z represents C(O)OR6, an optionally substituted 5- or 6-membered heteroaryl group or the like; and R1 and R2 represent H, a halogen atom or the like.

ENDO TSUYOSHI (JP)
TAKAHASHI RIE (JP)
KANAKUBO NORIKO (JP)
TAKAHASHI TOSHIHIRO (JP)
KUNIGAMI TOSHIHIRO (JP)

PCT/JP2012/054721

September 07, 2012

February 27, 2012

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NIPPON CHEMIPHAR CO (JP)
ENDO TSUYOSHI (JP)
TAKAHASHI RIE (JP)
KANAKUBO NORIKO (JP)
TAKAHASHI TOSHIHIRO (JP)
KUNIGAMI TOSHIHIRO (JP)

C07D401/14; A61K31/4545; A61K31/497; A61K31/506; A61P3/10; A61P43/00; C07D413/14; C07D471/04

WO2010013849A1	2010-02-04
WO2010095663A1	2010-08-26
WO2011025006A1	2011-03-03
WO2011093501A1	2011-08-04

JP2006518763A	2006-08-17
JP2006516572A	2006-07-06
JP2007528856A	2007-10-18
JP2008545007A	2008-12-11
JP2010501629A	2010-01-21
JP2010506847A	2010-03-04

Chigusa, Shinichi (JP)
1000 Shin-ichi Kusa (JP)

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