Title:
GRANULES COMPRISING PROGERININ, AND SACHETS USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/146211
Kind Code:
A1
Abstract:
The present invention relates to granules comprising Progerinin, capsules or sachets using same, and a preparation method therefor. More specifically, in order to develop a formulation that is advantageous when applying, to patients, Progerinin, which is a poorly water-soluble drug having a Hutchinson-Gilford progeria treatment effect, Progerinin granules comprising a specific water-soluble polymer, solubility enhancer and excipient at an optimum composition ratio have been developed and oral solid preparations such as capsules or sachets have been developed using the granules, such that dispersion stability and bioavailability of Progerinin can be improved and storage, transport and patient drug compliance can also be improved.
Inventors:
CHOI GANGSUN (KR)
Application Number:
PCT/KR2023/000926
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
PRG S&TECH INC (KR)
International Classes:
A61K9/16; A61K9/00; A61K31/365; A61K47/22; A61K47/38; A61P43/00
Domestic Patent References:
| WO2018199633A1 | 2018-11-01 |
Foreign References:
| JP2018035147A | 2018-03-08 | |||
| KR20050026705A | 2005-03-15 | |||
| KR102369827B1 | 2022-03-04 |
Other References:
GEORGE MAYA; GHOSH INDRAJIT: "Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 48, no. 1, 22 October 2012 (2012-10-22), NL , pages 142 - 152, XP028975341, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2012.10.004
LEE, K. ET AL: "Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 12, 1 December 2010 (2010-12-01), AMSTERDAM, NL , pages 5567 - 5575, XP027526514, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2010.09.006
LEE, K. ET AL: "Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 12, 1 December 2010 (2010-12-01), AMSTERDAM, NL , pages 5567 - 5575, XP027526514, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2010.09.006
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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