Title:
GRAPHENE-ENABLED DNA BIOESENSORS WITH ENHANCED SENSITIVITY AND SPECIFICITY
Document Type and Number:
WIPO Patent Application WO/2019/173725
Kind Code:
A3
Abstract:
Provided are electronic biosensors based on graphene field effect transistors that utilize engineered hairpin probe DNA that allows for target recycling and hybridization chain reactions.
Inventors:
JOHNSON JR (US)
GAO ZHAOLI (US)
XIA HAN (CN)
GAO ZHAOLI (US)
XIA HAN (CN)
Application Number:
PCT/US2019/021367
Publication Date:
October 24, 2019
Filing Date:
March 08, 2019
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
International Classes:
G01N27/407; G01N27/327; G01N27/411; G01N27/414; G01N33/487
Other References:
WANG ET AL.: "Graphene sheets, polyaniline and AuNPs based DNA sensor for electrochemical determination of BCR/ABL fusion gene with functional hairpin probe", BIOSENS BIOELECTRON, vol. 51, 2014, pages 201 - 207, XP055473819, DOI: 10.1016/j.bios.2013.07.049
YANG ET AL.: "A cascade amplification strategy of catalytic hairpin assembly and hybridization chain reaction for the sensitive fluorescent assay of the model protein carcinoembryonic antigen", MIKROCHIM ACTA, vol. 185, no. 2, 10 January 2018 (2018-01-10), pages 100, XP036394225, DOI: 10.1007/s00604-017-2620-6
GAO ET AL.: "Scalable Production of Sensor Arrays Based on High-Mobility Hybrid Graphene Field Effect Transistors", ACS APPL MATER INTERFACES, vol. 8, no. 41, 2016, pages 27546 - 27552, XP055643896
YANG ET AL.: "A cascade amplification strategy of catalytic hairpin assembly and hybridization chain reaction for the sensitive fluorescent assay of the model protein carcinoembryonic antigen", MIKROCHIM ACTA, vol. 185, no. 2, 10 January 2018 (2018-01-10), pages 100, XP036394225, DOI: 10.1007/s00604-017-2620-6
GAO ET AL.: "Scalable Production of Sensor Arrays Based on High-Mobility Hybrid Graphene Field Effect Transistors", ACS APPL MATER INTERFACES, vol. 8, no. 41, 2016, pages 27546 - 27552, XP055643896
Attorney, Agent or Firm:
RABINOWITZ, Aaron, B. (US)
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