Title:
A GROUP OF B7H3 MONOCLONAL ANTIBODIES AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/257893
Kind Code:
A1
Abstract:
Provided are a group of anti-B7H3 monoclonal antibodies and humanized antibodies thereof. The antibodies obtained by means of hybridoma technology have B7H3 affinity, cell endocytosis effect, and antibody-dependent cytotoxicity, or can effectively block an immunosuppressive effect caused by B7H3, and can be used for preparing related drugs for inhibiting cancer cells, regulating the effect and level of B7H3, and enhancing the immunity of an organism.
Inventors:
QIU JUNZHUAN (CN)
WANG ZHENSHENG (CN)
SUN KAI (CN)
CHEN JUNYONG (CN)
SUN JIAN (CN)
LI ZHONGLIANG (CN)
OU RISHAN (CN)
WANG ZHENSHENG (CN)
SUN KAI (CN)
CHEN JUNYONG (CN)
SUN JIAN (CN)
LI ZHONGLIANG (CN)
OU RISHAN (CN)
Application Number:
PCT/CN2022/097193
Publication Date:
December 15, 2022
Filing Date:
June 06, 2022
Export Citation:
Assignee:
INNOLAKE BIOPHARMA HANGZHOU CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61K47/68; A61P35/00; A61P37/04
Domestic Patent References:
| WO2017180813A1 | 2017-10-19 |
Foreign References:
| CN113402610A | 2021-09-17 | |||
| CN112851812A | 2021-05-28 | |||
| US20190338030A1 | 2019-11-07 | |||
| US20170369585A1 | 2017-12-28 | |||
| CN111944050A | 2020-11-17 | |||
| CN111235113A | 2020-06-05 | |||
| US8802091B2 | 2014-08-12 |
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SUN M. ET AL., J. IMMUNOL., vol. 168, 2002, pages 6294
LOOS M., CLIN. DEV. IMMUNOL., 2010, pages 683875
PRASAD D. V. R. ET AL., J. IMMUNOL., vol. 173, 2004, pages 2500
GREENWALD R. J. ET AL., ANNU. REV. IMMUNOL., vol. 23, 2005, pages 515 - 48
HOFMEYER K. A. ET AL., PROC. NATL. ACAD. SCI., vol. 105, 2008, pages 10277
CALABRO L. ET AL., J. CELL PHYSIOL., vol. 226, 2011, pages 2595
SUH W. K. ET AL., NAT. IMMUNOL, vol. 4, 2003, pages 899
WANG L. ET AL., EUR. J. IMMUNOL., vol. 35, 2005, pages 428
VIGDOROVICH V. ET AL., STRUCTURE, vol. 21, 2013, pages 707
CASTRICONI R. ET AL., PROC. NATL. ACAD. SCI., vol. 101, 2004, pages 12640
MAHNKE K. ET AL., EUR. J. IMMUNOL., vol. 37, 2007, pages 2117
SUH W. K. ET AL., NAT. IMMUNOL., vol. 4, 2003, pages 899
WANG J. ET AL., J. INVEST. DERMATOL., vol. 133, 2013, pages 2050
HU Y ET AL., HEMATOLOGY, vol. 20, 2015, pages 187
SUN J. ET AL., ONCOTARGETS THER, vol. 7, 2014, pages 1979
ZANG X. ET AL., PROC. NATL. ACAD. SCI., vol. 104, 2007, pages 19458
ZANG X. ET AL., MOD. PATHOL., vol. 23, 2010, pages 1104
CHEN Y ET AL., ONCO. TARGETS THER., vol. 7, 2014, pages 1465 - 72
XU H. ET AL., CANCER RES., vol. 69, 2009, pages 6275
PICARDA E. ET AL., CLIN. CANCER RES., vol. 22, 2016, pages 3425
ZHANG T. ET AL., WORLD J. GASTROENTEROL., vol. 21, 2015, pages 1804
TEKLE C. ET AL., INT. J CANCER, vol. 130, 2013, pages 2282
LI Y ET AL., ONCOTARGET, vol. 8, 2017, pages 71725
WANG L. ET AL., PLOS ONE, vol. 8, 2013, pages e70689
LIU F. ET AL., MOL. MED. REP., vol. 12, 2015, pages 5455
TEKLE C. ET AL., INT. J. CANCER, vol. 130, 2012, pages 2282
FERRARA N. ET AL., NAT. REV. CANCER, vol. 2, 2002, pages 795
JIANG ET AL., ONCOTARGET, 2016, pages 731755
SHI T. ET AL., CELL DEATH DIS., vol. 10, 2019, pages 308
LIM S. ET AL., CANCER RES., vol. 76, 2016, pages 2231
FLEM-KARLSEN K. ET AL., PIGMENT CELL MELANOMA RES., vol. 30, 2017, pages 467
KASTEN B. B. ET AL., NUCL. MED. BIOL., vol. 47, 2017, pages 23
LIU H. ET AL., MOL. CANCER THER., vol. 10, 2011, pages 960
CAI D. ET AL., CELL. MOL. IMMUNOL., vol. 17, 2020, pages 227
LEE Y H. ET AL., CELL RES., vol. 27, 2017, pages 1034
KOENIG S. ET AL., MEDICOGRAPHIA, vol. 36, 2014, pages 285
KABAT, E.A. ET AL., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST, 1991
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
"Remington, The Science and Practice of Pharmacy", 2005, MACK PUBLISHING
KETTLEBOROUGH ET AL., EUR. J IMMUNOLOGY, vol. 23, 1993, pages 206 - 211
STREBE, ANTIBODY ENGINEERING, vol. 1, 2010, pages 3 - 14
Attorney, Agent or Firm:
ZHONG LUN LAW FIRM (CN)
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