A GROWTH HORMONE FUSION PROTEIN AND ITSUSE THEREOF - SHENZHEN KEXING PHARMACEUTICAL CO LTD

Title:

A GROWTH HORMONE FUSION PROTEIN AND ITSUSE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/065700

Kind Code:

A1

Abstract:

Provided herein are a growth hormone fusion protein and its use thereof. The fusion protein comprises an Fc mutant, wherein the Fc mutant comprises the first peptide chain, wherein the first peptide chain 1) comprises mutantions at the following positions in comparision to a wild-type IgG4 Fc fragment: at least one of amino acid in positions 234, 235, 298, 299, and 300; Or positions 231-239; Or 2) comprising mutantions at the following positions in comparision to a wild-type IgG1 Fc fragment: positions 228-239, and/or, at least one of amino acid in positions 268, 296, 330 and 331.

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Inventors:

QIN SUOFU (CN)
YAN CHENGWEI (CN)
QIU YUXIN (CN)
GUO NINING (CN)

Application Number:

PCT/CN2022/100240

Publication Date:

April 27, 2023

Filing Date:

June 21, 2022

Export Citation:

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Assignee:

SHENZHEN KEXING PHARMACEUTICAL CO LTD (CN)

International Classes:

A61K38/27; A61K47/68; A61P5/06; C07K14/00; C07K19/00; C12N5/10; C12N15/18; C12N15/62; C12N15/85

Foreign References:

CN102875683A	2013-01-16
CN107206257A	2017-09-26
US20100098710A1	2010-04-22
CN104797598A	2015-07-22
CN110177567A	2019-08-27
CN109152816A	2019-01-04
CN110256575A	2019-09-20

Other References:

Y，L. ET AL.: "Construction and screening of rhGH-Fc engineering cells.", CHIN J BIOLOGICALS., vol. 29, no. 10, 17 October 2016 (2016-10-17), pages 1021 - 1026, XP009545123
KU CHEOL RYONG, BRUE THIERRY, SCHILBACH KATHARINA, IGNATENKO STANISLAV, MAGONY SANDOR, CHUNG YOON-SOK, KIM BYUNG-JOON, HUR KYU YEO: "Long-acting FC-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 179, no. 3, 1 September 2018 (2018-09-01), GB , pages 169 - 179, XP093059329, ISSN: 0804-4643, DOI: 10.1530/EJE-18-0185

Attorney, Agent or Firm:

ZHIFAN & PARTNERS (CN)

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