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Title:
GUANIDINE DERIVATIVE AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/159650
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound which has a guanidine skeleton and inhibits the protease activity of MALT1 to exhibit a therapeutic effect or prophylactic effect on autoimmune diseases such as psoriasis. The present invention provides the guanidine derivative represented by the following formula or a pharmacologically acceptable salt thereof.

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Inventors:
NUMAJIRI YOSHITAKA (JP)
OKIMURA KEIICHI (JP)
ASABA KENNUNETTSU (JP)
KOREEDA TETSURO (JP)
ISEKI KATSUHIKO (JP)
TOKUMARU KAZUYUKI (JP)
GOTO YASUFUMI (JP)
Application Number:
PCT/JP2018/007416
Publication Date:
September 07, 2018
Filing Date:
February 28, 2018
Export Citation:
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Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07C311/64; A61K31/155; A61K31/341; A61K31/381; A61P17/06; A61P37/06; A61P43/00; C07C279/22; C07C323/44; C07D307/64; C07D333/34; C07D333/38
Domestic Patent References:
WO2015181747A12015-12-03
WO2018021520A12018-02-01
WO2017057695A12017-04-06
Foreign References:
JP2015536990A2015-12-24
JP2014521678A2014-08-28
JP2008516934A2008-05-22
JP2005534620A2005-11-17
JP2003503311A2003-01-28
JP2017214315A2017-12-07
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