Title:
GUANIDINIUM TRANSPORT REAGENTS AND CONJUGATES
Document Type and Number:
WIPO Patent Application WO2003049772
Kind Code:
A3
Abstract:
Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed from the backbone via tethers, to allow their interaction with a cell or tissue surface, leading to uptake of the therapeutic agent.
Inventors:
ROTHBARD JONATHAN B (US)
WENDER PAUL A (US)
PATTABIRAMAN KANAKA (US)
PELKEY ERIN T (US)
JESSOP THEODORE C (US)
WENDER PAUL A (US)
PATTABIRAMAN KANAKA (US)
PELKEY ERIN T (US)
JESSOP THEODORE C (US)
Application Number:
PCT/US2002/039698
Publication Date:
November 20, 2003
Filing Date:
December 11, 2002
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
CELLGATE INC (US)
ROTHBARD JONATHAN B (US)
WENDER PAUL A (US)
PATTABIRAMAN KANAKA (US)
PELKEY ERIN T (US)
JESSOP THEODORE C (US)
CELLGATE INC (US)
ROTHBARD JONATHAN B (US)
WENDER PAUL A (US)
PATTABIRAMAN KANAKA (US)
PELKEY ERIN T (US)
JESSOP THEODORE C (US)
International Classes:
A61K31/395; A61K31/4188; A61K47/48; A61P29/00; A61P31/04; A61P31/10; A61P35/00; A61P43/00; (IPC1-7): A61K47/48
Other References:
WENDER PAUL A ET AL: "The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 97, no. 24, 21 November 2000 (2000-11-21), pages 13003 - 13008, XP002247290, ISSN: 0027-8424
FUCHS STEPHEN M ET AL: "Effect of guanidinium display on the translocation of molecules through membranes.", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 222, no. 1-2, 1 January 2001 (2001-01-01), pages BIOL213, XP008019499, ISSN: 0065-7727
WENDER PAUL A ET AL: "Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 13 NOV 2002, vol. 124, no. 45, 13 November 2002 (2002-11-13), pages 13382 - 13383, XP002251160, ISSN: 0002-7863
ROTHBARD JONATHAN B ET AL: "Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake.", JOURNAL OF MEDICINAL CHEMISTRY. 15 AUG 2002, vol. 45, no. 17, 15 August 2002 (2002-08-15), pages 3612 - 3618, XP001159667, ISSN: 0022-2623
ROTHBARD, JONATHAN B. ET AL: "Arginine-rich molecular transporters for drugs: the role of backbone and side chain variations on cellular uptake", CELL-PENETRATING PEPTIDES (2002), 141-160. EDITOR(S): LANGEL, UELO. PUBLISHER: CRC PRESS LLC, BOCA RATON, FLA. CODEN: 69EAO3; ISBN: 0-8493-1141-1, 2002, XP001159671
See also references of EP 1461084A2
FUCHS STEPHEN M ET AL: "Effect of guanidinium display on the translocation of molecules through membranes.", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 222, no. 1-2, 1 January 2001 (2001-01-01), pages BIOL213, XP008019499, ISSN: 0065-7727
WENDER PAUL A ET AL: "Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 13 NOV 2002, vol. 124, no. 45, 13 November 2002 (2002-11-13), pages 13382 - 13383, XP002251160, ISSN: 0002-7863
ROTHBARD JONATHAN B ET AL: "Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake.", JOURNAL OF MEDICINAL CHEMISTRY. 15 AUG 2002, vol. 45, no. 17, 15 August 2002 (2002-08-15), pages 3612 - 3618, XP001159667, ISSN: 0022-2623
ROTHBARD, JONATHAN B. ET AL: "Arginine-rich molecular transporters for drugs: the role of backbone and side chain variations on cellular uptake", CELL-PENETRATING PEPTIDES (2002), 141-160. EDITOR(S): LANGEL, UELO. PUBLISHER: CRC PRESS LLC, BOCA RATON, FLA. CODEN: 69EAO3; ISBN: 0-8493-1141-1, 2002, XP001159671
See also references of EP 1461084A2
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