Title:
GUANIDINOBENZOIC ACID ESTER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/142219
Kind Code:
A1
Abstract:
[Problem] To provide a compound useful as a drug for preventing and/or treating kidney disease.
[Solution] The inventors studied compounds having trypsin-inhibiting activity, confirmed that guanidinobenzoic acid ester compounds have trypsin-inhibiting activity, and completed the invention. These guanidinobenzoic acid ester compounds can be used as drugs for the prevention and/or treatment of kidney disease (for example, chronic kidney disease, acute glomerulonephritis, acute renal failure, and the like) as alternative drugs to a low-protein diet, and/or as drugs for the prevention and/or treatment of diseases in which trypsin participates (for example, chronic pancreatitis, reflux esophagitis, hepatic encephalopathy, influenza, and the like).
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Inventors:
FUJIYASU JIRO (JP)
ASANO TORU (JP)
YAMAKI SUSUMU (JP)
KANEKO OSAMU (JP)
KOIKE YUKA (JP)
IMAIZUMI TOMOYOSHI (JP)
URANO YASUHARU (JP)
SATOU TOMOHKI (JP)
SASAMURA SATOSHI (JP)
ASANO TORU (JP)
YAMAKI SUSUMU (JP)
KANEKO OSAMU (JP)
KOIKE YUKA (JP)
IMAIZUMI TOMOYOSHI (JP)
URANO YASUHARU (JP)
SATOU TOMOHKI (JP)
SASAMURA SATOSHI (JP)
Application Number:
PCT/JP2014/056601
Publication Date:
September 18, 2014
Filing Date:
March 13, 2014
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C07C279/18; A61K31/24; A61K31/343; A61K31/381; A61K31/472; A61P13/12; C07D217/26; C07D307/80; C07D333/40; C07D333/68; C07D333/70
Domestic Patent References:
| WO2011071048A1 | 2011-06-16 | |||
| WO1997037969A1 | 1997-10-16 | |||
| WO1994013631A1 | 1994-06-23 | |||
| WO1991018869A1 | 1991-12-12 | |||
| WO2011071048A1 | 2011-06-16 | |||
| WO1997037969A1 | 1997-10-16 | |||
| WO2006083781A1 | 2006-08-10 |
Foreign References:
| JPH09124571A | 1997-05-13 | |||
| JPS5753454A | 1982-03-30 | |||
| JPS5289640A | 1977-07-27 | |||
| JPS5289640A | 1977-07-27 | |||
| JPS5753454A | 1982-03-30 | |||
| JPH0753500A | 1995-02-28 | |||
| JPH0848664A | 1996-02-20 | |||
| JPH09124571A | 1997-05-13 | |||
| JPH10306025A | 1998-11-17 | |||
| JPH06192085A | 1994-07-12 |
Other References:
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 321, no. 26, 1989, pages 1773 - 1777
AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 41, no. 3, 2003, pages S31 - S34
EVIDENCE-BASED CLINICAL PRACTICE GUIDELINE FOR CKD 2013, 2013, pages 25 - 30
NEPHRON, vol. 74, no. 4, 1996, pages 709 - 712
CLINICAL NEPHROLOGY, vol. 32, 1989, pages 119 - 123
ANTIVIRAL RESEARCH, vol. 92, no. 1, 2011, pages 27 - 36
"Protease Groups of Individuals which Determine Susceptibility to Infection of Influenza Virus and Pathogenesis of Influenza-Associated Encephalopathy", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 122, 2003, pages 45 - 53
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. REENE: "Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 12, 2003, pages 2446 - 2455
TETRAHEDRON LETTERS, vol. 34, no. 21, 1993, pages 3389 - 3392
M. HUDLICKY: "ACS Monograph: 188", 1996, ACS, article "Reductions in Organic Chemistry"
"Jikken Kagaku Koza", vol. 19, 2005, MARUZEN
"Anti-mouse Trypsin Antibody", SANTA CRUZ BIOTECHNOLOGY, INC.
AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 41, no. 3, 2003, pages S31 - S34
EVIDENCE-BASED CLINICAL PRACTICE GUIDELINE FOR CKD 2013, 2013, pages 25 - 30
NEPHRON, vol. 74, no. 4, 1996, pages 709 - 712
CLINICAL NEPHROLOGY, vol. 32, 1989, pages 119 - 123
ANTIVIRAL RESEARCH, vol. 92, no. 1, 2011, pages 27 - 36
"Protease Groups of Individuals which Determine Susceptibility to Infection of Influenza Virus and Pathogenesis of Influenza-Associated Encephalopathy", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 122, 2003, pages 45 - 53
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Molecular Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. REENE: "Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 12, 2003, pages 2446 - 2455
TETRAHEDRON LETTERS, vol. 34, no. 21, 1993, pages 3389 - 3392
M. HUDLICKY: "ACS Monograph: 188", 1996, ACS, article "Reductions in Organic Chemistry"
"Jikken Kagaku Koza", vol. 19, 2005, MARUZEN
"Anti-mouse Trypsin Antibody", SANTA CRUZ BIOTECHNOLOGY, INC.
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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