GUANIDINOMETHYL CYCLOHEXANE CARBOXYLIC ESTER DERIVATIVE

Title:

GUANIDINOMETHYL CYCLOHEXANE CARBOXYLIC ESTER DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1996/006825

Kind Code:

A1

Abstract:

A compound represented by general formula (I-2) or a pharmaceutically acceptable acid-addition salt thereof, useful as an anti-microbial against Helicobacter pylori and as a medicinal composition for treating Helicobacter pylori infection, wherein Ar represents phenyl, biphenyl or naphthyl each having at leat one substituent selected from the group consisting of halogeno, cyano, nitro, carboxy, C1-C18 alkyl, C1-C18 alkoxy, C3-C18 cycloalkyl, C7-C18 aralkyl, C8-C18 arylalkenyl, C7-C18 aralkyloxy, optionally substituted phenoxy, optionally substituted C2-C19 alkoxycarbonyl, and optionally substituted C8-C19 aralkyloxycarbonyl, provided the case where Ar represents phenyl substituted by halogeno, cyano, nitro, carboxy, C1-C18 alkyl, optionally substituted C2-C19 alkoxycarbonyl or C8-C19 aralkyloxycarbonyl is expected.

Inventors:

KAMODA OSAMU (JP)
FUJIWARA HIROMICHI (JP)
YANAGI TOSHIHARU (JP)

Application Number:

PCT/JP1995/001725

Publication Date:

March 07, 1996

Filing Date:

August 30, 1995

Export Citation:

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Assignee:

TEIKOKU CHEMICAL IND CO LTD (JP)
KAMODA OSAMU (JP)
FUJIWARA HIROMICHI (JP)
YANAGI TOSHIHARU (JP)

International Classes:

A61K31/215; A61K31/24; C07C69/94; C07C279/14; (IPC1-7): C07C279/14; A61K31/215; A61K31/275

Foreign References:

JPS57122059A	1982-07-29
JPS5645454A	1981-04-25
JPS5692261A	1981-07-25
JPS5716856A	1982-01-28
JPS5716855A	1982-01-28
JPS6254A	1987-01-06
JPS63218652A	1988-09-12

Other References: