Title:
CRISPR/RNA-GUIDED NUCLEASE SYSTEMS AND METHODS
Document Type and Number:
WIPO Patent Application WO/2018/209158
Kind Code:
A3
Abstract:
Genome editing systems, guide RNAs, dead guide RNAs, and CRISPR-mediated methods are provided for altering portions of a target nucleic acid.
Inventors:
AUPEPIN DE LAMOTHE-DREUZY EDOUARD (US)
HEATH JACK (US)
GORI JENNIFER LEAH (US)
BARRERA LUIS (US)
HEATH JACK (US)
GORI JENNIFER LEAH (US)
BARRERA LUIS (US)
Application Number:
PCT/US2018/032172
Publication Date:
January 03, 2019
Filing Date:
May 10, 2018
Export Citation:
Assignee:
EDITAS MEDICINE INC (US)
International Classes:
C12N15/11
Domestic Patent References:
| WO2016094872A1 | 2016-06-16 | |||
| WO2014197748A2 | 2014-12-11 | |||
| WO2016205613A1 | 2016-12-22 | |||
| WO2017035416A2 | 2017-03-02 | |||
| WO2016205749A1 | 2016-12-22 |
Other References:
YANFANG FU ET AL: "Improving CRISPR-Cas nuclease specificity using truncated guide RNAs", NATURE BIOTECHNOLOGY, vol. 32, no. 3, 26 January 2014 (2014-01-26), US, pages 279 - 284, XP055259718, ISSN: 1087-0156, DOI: 10.1038/nbt.2808
FU Y ET AL: "Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAsc", USE OF CRISPR/CAS9, ZFNS, AND TALENS IN GENERATING SITE-SPECIFIC GENOME ALTERATIONS IN: METHODS IN ENZYMOLOGY; ISSN 1557-7988; VOL; [METHODS IN ENZYMOLOGY; ISSN 1557-7988; VOL. 546], ELSEVIER, NL, vol. 546, 1 January 2014 (2014-01-01), pages 21 - 45, XP008179585, ISBN: 978-0-12-801185-0, [retrieved on 20141112]
FU Y ET AL: "Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAsc", USE OF CRISPR/CAS9, ZFNS, AND TALENS IN GENERATING SITE-SPECIFIC GENOME ALTERATIONS IN: METHODS IN ENZYMOLOGY; ISSN 1557-7988; VOL; [METHODS IN ENZYMOLOGY; ISSN 1557-7988; VOL. 546], ELSEVIER, NL, vol. 546, 1 January 2014 (2014-01-01), pages 21 - 45, XP008179585, ISBN: 978-0-12-801185-0, [retrieved on 20141112]
Attorney, Agent or Firm:
PROCHNOW, Courtney (US)
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