Title:
H1N1 FLU VIRUS NEUTRALIZING ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2017/028731
Kind Code:
A1
Abstract:
An antibody, or a binding fragment of the antibody, against H1N1 virus, includes a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region contains complementarity determining regions (CDR) that have the amino acid sequences of SEQ ID NO: 5, SEQ ID NO: 6, and SEQ ID NO: 7; and wherein the light chain variable region contains complementarity determining regions that have the amino acid sequences of SEQ ID NO: 8, SEQ ID NO: 9, and SEQ ID NO: 10. A method for treating or preventing H1N1 infection in a subject includes administering to the subject the antibody or the binding fragment of the antibody.
Inventors:
LIN YOUNG-SUN (CN)
LAI KUEI-TAI (CN)
HUANG HUEI-LUEN (CN)
HSU HSIANG-TING (CN)
CHEN WAN-CHEN (CN)
CHEN YA-LIN (CN)
WONG CHIA-WEN (CN)
LAI KUEI-TAI (CN)
HUANG HUEI-LUEN (CN)
HSU HSIANG-TING (CN)
CHEN WAN-CHEN (CN)
CHEN YA-LIN (CN)
WONG CHIA-WEN (CN)
Application Number:
PCT/CN2016/094494
Publication Date:
February 23, 2017
Filing Date:
August 11, 2016
Export Citation:
Assignee:
MEDIGEN BIOTECHNOLOGY CORP (CN)
International Classes:
C07K16/10; A61K39/42; A61P31/16; C12N5/10; C12N15/63; G01N33/53
Domestic Patent References:
| WO2011111966A2 | 2011-09-15 |
Foreign References:
| CN102241768A | 2011-11-16 |
Other References:
WANG, H. ET AL.: "Generation of human neutralizing monoclonal antibodies against the 2009 pandemic H1N1 virus from peripheral blood memory B lymphocytes.", CELLULAR & MOLECULAR IMMUNOLOGY, vol. 10, no. 5, 5 August 2013 (2013-08-05), pages 403 - 412, XP055364218
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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