Title:
HLA-A11-RESTRICTED Tax ANTITUMOR EPITOPES
Document Type and Number:
WIPO Patent Application WO/2006/035681
Kind Code:
A1
Abstract:
It is intended to provide peptides having an activity of inducing cytotoxic T lymphocytes (CTL) specific to human T-cell leukemia virus type I (HTLV-I) that has an antitumor effect on HTLV-I tumor such as adult T-cell leukemia (ATL); and vaccines for inducing an immune response, diagnostics for testing an immune function and so on with the use of the same. By examining cellular immune responses in a patient achieving a complete remission after hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling donor, it is found out that in a liquid culture of peripheral blood mononuclear cells (PBMC) of the ATL patient after the HSCT, HTLV-I-specific CTL are selectively induced by HLA-A11-restricted Tax 88-96 and HLA-A11-restricted Tax 272-280 epitopes which have vigorously proliferated in response to auto HTLV-I infected T cells constructed in vitro before the HSCT. This phenomenon indicates that these epitopes are strongly expressed in the patient, suggesting the usefulness of these epitopes as vaccine antigens.
Inventors:
HARASHIMA NANAE (JP)
KANNAGI MARI (JP)
TANOZAKI RYUJI (JP)
KANNAGI MARI (JP)
TANOZAKI RYUJI (JP)
Application Number:
PCT/JP2005/017527
Publication Date:
April 06, 2006
Filing Date:
September 22, 2005
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MED & DENT (JP)
HARASHIMA NANAE (JP)
KANNAGI MARI (JP)
TANOZAKI RYUJI (JP)
HARASHIMA NANAE (JP)
KANNAGI MARI (JP)
TANOZAKI RYUJI (JP)
International Classes:
C12N15/09; A61K39/21; A61P31/14; C07K7/06; C07K16/10; C07K19/00
Domestic Patent References:
| WO2004092373A1 | 2004-10-28 |
Foreign References:
| JP2002507397A | 2002-03-12 |
Other References:
BIEGANOWSKA K ET AL: "Direct Analysis of Viral-Specific CD8+ T Cells with Soluble HLA-A2/Tax11-19 Tetramer Complexes in Patients with Human T Cell Lymphotropic Virus-Associated Myelopathy.", J IMMUNOL., vol. 162, 1999, pages 1765 - 1771, XP002994978
PARKER C E ET AL: "Circulating Anti-Tax Cytotoxic T Lymphocytes from Human T-Cell Leukemia Virus Type I-Infected People with and without Tropical Spastic Paraparesis, Recognize Multiple Epitopes simultaneously.", J VIROL., vol. 68, no. 5, 1994, pages 2860 - 2868, XP002994979
HARASHIMA N ET AL: "Graft-versus-Tax Response in Adult T-Cell Leukemia Patients after Hematopoietic Stem Cell Transplantation.", CANCRE RESEARCH., vol. 64, January 2004 (2004-01-01), pages 391 - 399, XP002980966
HARASHIMA N ET AL: "Identification of two New HLA-A*1101-Restricted Tax Epitopes Recognized by Cytotoxic T Lymphocytes in an Adult T-Cell Leukemia Patient After Hematopoietic Stem Cell Transplantation.", J VIROLOGY., vol. 79, no. 15, August 2005 (2005-08-01), pages 10088 - 10092, XP002994980
KANNAGI M ET AL: "Target Epitope in the Tax Protein of Human T-Cell Leukemia Virus Type I Recognized by Class I Major Histocompatibility Complex-Restricted Cytotoxic T Cells.", J VIROLOGY., vol. 66, no. 5, 1992, pages 2928 - 2933, XP000857308
PARKER C E ET AL: "Circulating Anti-Tax Cytotoxic T Lymphocytes from Human T-Cell Leukemia Virus Type I-Infected People with and without Tropical Spastic Paraparesis, Recognize Multiple Epitopes simultaneously.", J VIROL., vol. 68, no. 5, 1994, pages 2860 - 2868, XP002994979
HARASHIMA N ET AL: "Graft-versus-Tax Response in Adult T-Cell Leukemia Patients after Hematopoietic Stem Cell Transplantation.", CANCRE RESEARCH., vol. 64, January 2004 (2004-01-01), pages 391 - 399, XP002980966
HARASHIMA N ET AL: "Identification of two New HLA-A*1101-Restricted Tax Epitopes Recognized by Cytotoxic T Lymphocytes in an Adult T-Cell Leukemia Patient After Hematopoietic Stem Cell Transplantation.", J VIROLOGY., vol. 79, no. 15, August 2005 (2005-08-01), pages 10088 - 10092, XP002994980
KANNAGI M ET AL: "Target Epitope in the Tax Protein of Human T-Cell Leukemia Virus Type I Recognized by Class I Major Histocompatibility Complex-Restricted Cytotoxic T Cells.", J VIROLOGY., vol. 66, no. 5, 1992, pages 2928 - 2933, XP000857308
Attorney, Agent or Firm:
Hirota, Masanori (8-5 Akasaka 2-chome, Minato-ku Tokyo, JP)
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