HYDROCHLORIDE 2,3,3a,4,5,6-HEXAHYDRO-8-CYCLOHEXYL-1H-PYRAZINO (3,2,1-j,k)CARBAZOL, METHOD OF OBTAINING IT AND A PHARMACEUTICAL PREPARATION OF ANTIDEPRESSIVE ACTION BASED ON IT

Title:

HYDROCHLORIDE 2,3,3a,4,5,6-HEXAHYDRO-8-CYCLOHEXYL-1H-PYRAZINO (3,2,1-j,k)CARBAZOL, METHOD OF OBTAINING IT AND A PHARMACEUTICAL PREPARATION OF ANTIDEPRESSIVE ACTION BASED ON IT

Document Type and Number:

WIPO Patent Application WO/1991/007968

Kind Code:

A1

Abstract:

Hydrochloride 2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1H-pyrazino (3,2,1-j,k)carbazol has formula (I). A method of obtaining the claimed composition consists in that 6-cyclohexyl-3,4-dihydrocarbazol-1(2H) is alkylated by hydrochloride beta-(N,N-dibenzylamino) ethylchloride in a two-phase system: an aromatic hydrocarbon-30-40 %-aqueous solution of alkali in the presence of an interphase transfer catalyst at a temperature of 85-110 °C with subsequent hydrogenation of the resulting 6-cyclohexyl-9beta-(N,N-dibenzylamino) ethyl-3,4-dihydrocarbazol-1(2H) over palladium catalyst on a carrier in the medium of a higher aliphatic alcohol at a temperature of 50-70 °C and under a pressure of 1 to 30 atm with subsequent transfer of the obtained 2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1H-pyrazino (3,2,1-j,k)carbazol into hydrochloride and extraction of the latter. The claimed composition has an antidepressive action and is an active substance of a pharmaceutical preparation with antidepressive action.

Inventors:

SHVEDOV VASILY IVANOVICH (SU)
MASHKOVSKY MIKHAIL DAVYDOVICH (SU)
SAVITSKAYA NINA VIKTOROVNA (SU)
ANDREEVA NATALIA IVANOVNA (SU)
FEDOROVA IRINA NIKOLAEVNA (SU)
GUSKOVA TATYANA ANATOLIEVNA (SU)
TUPIKINA SVETLANA MIKHAILOVNA (SU)
VERSTAKOVA OLGA LVOVNA (SU)
NYRKOVA VALENTINA GEORGIEVNA (SU)
KONYAEVA IRINA PAVLOVNA (SU)
ALTUKHOVA LJUDMILA BENEDIKTOVN (SU)
AKALAEVA TATYANA VASILIEVNA (SU)
ASNINA VALENTINA VASILIEVNA (SU)
GORKIN VLADIMIR ZINOVIEVICH (SU)
VEREVKINA IREN VLADIMIROVNA (SU)

Application Number:

PCT/SU1989/000302

Publication Date:

June 13, 1991

Filing Date:

November 27, 1989

Export Citation:

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Assignee:

GRINEVA GALINA VASILIEVNA & LF (SU)
VNI KHIM FARMATS (SU)

International Classes:

A61K31/495; A61P25/24; A61P25/26; C07D487/06; (IPC1-7): A61K9/20; A61K31/495; C07D209/86; C07D487/04

Foreign References:

US4400383A	1983-08-23
SU906380A3	1982-02-15
US3959470A	1976-05-25
SU276061A1	1975-11-05
GB1340529A	1973-12-12

Other References: