Title:
HAIR-GROWTH MICRONEEDLE PATCH CONTAINING ANDROGEN RECEPTOR-PROTEOLYSIS TARGETING CHIMERIC MOLECULES, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217028
Kind Code:
A1
Abstract:
Provided is a hair-growth microneedle patch containing androgen receptor-proteolysis targeting chimeric molecules. The hair-growth microneedle patch comprises a sheet-like backing and a soluble microneedle body arranged on the sheet-like backing and containing androgen receptor-proteolysis targeting chimeric molecules. The soluble microneedle body comprises one or more of the androgen receptor-proteolysis targeting chimeric molecules, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, an ester thereof, a prodrug thereof, a solvate thereof, a metabolite thereof, a nitrogen oxide thereof, or a deuterated compound thereof. Also provided are a preparation method for the hair-growth microneedle patch containing the androgen receptor-proteolysis targeting chimeric molecules and use thereof in the preparation of a drug for treating androgenetic alopecia. The patch has the advantages of being safe, efficient and convenient to use.
Inventors:
GAO JIANQING (CN)
QIN CHONG (CN)
WANG RUXUAN (CN)
ZHONG TENGJIANG (CN)
QIN CHONG (CN)
WANG RUXUAN (CN)
ZHONG TENGJIANG (CN)
Application Number:
PCT/CN2023/092479
Publication Date:
November 16, 2023
Filing Date:
May 06, 2023
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
OCEAN UNIV CHINA (CN)
OCEAN UNIV CHINA (CN)
International Classes:
A61K9/00; A61K31/496; A61K47/66; A61P5/28; A61P17/14; C07D401/14
Domestic Patent References:
| WO2022011205A1 | 2022-01-13 | |||
| WO2019088315A1 | 2019-05-09 |
Foreign References:
| CN114848578A | 2022-08-05 | |||
| CN113041488A | 2021-06-29 | |||
| CN111544573A | 2020-08-18 | |||
| CN112153957A | 2020-12-29 | |||
| CN113620931A | 2021-11-09 |
Other References:
XIANG, WEIGUO ET AL.: "Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, no. 18, 2 September 2021 (2021-09-02), XP055878327, DOI: 10.1021/acs.jmedchem.1c00900
WANG RUXUAN, ZHONG TENGJIANG, BIAN QIONG, ZHANG SAI, MA XIAOLU, LI LIMING, XU YIHUA, GU YUETING, YUAN ANRAN, HU WEITONG, QIN CHONG: "PROTAC Degraders of Androgen Receptor‐Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration", SMALL METHODS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 7, no. 1, 1 January 2023 (2023-01-01), DE , XP093107214, ISSN: 2366-9608, DOI: 10.1002/smtd.202201293
WANG RUXUAN, ZHONG TENGJIANG, BIAN QIONG, ZHANG SAI, MA XIAOLU, LI LIMING, XU YIHUA, GU YUETING, YUAN ANRAN, HU WEITONG, QIN CHONG: "PROTAC Degraders of Androgen Receptor‐Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration", SMALL METHODS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 7, no. 1, 1 January 2023 (2023-01-01), DE , XP093107214, ISSN: 2366-9608, DOI: 10.1002/smtd.202201293
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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