Title:
HAIR-GROWTH PROMOTING COMPOSITION AND USAGE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/069113
Kind Code:
A1
Abstract:
The present invention relates to providing a new hair-growth or hair-restoration promoting composition or a composition that prevents hair loss. More specifically, provided is a composition containing an iNOS inhibitor as an active ingredient. The present invention achieves an advantageous effect of hair growth or hair restoration by injecting the composition containing the iNOS inhibitor as the active ingredient into a mammal. The iNOS inhibitor used may be a low-molecular compound, an antibody, or into a nucleic acid medicine, such as an antisense oligo or siRNA. Also provided is a method for screening effective substances for promoting hair growth or hair restoration or for preventing hair loss.
Inventors:
SHINOZAKI SHOHEI (JP)
SHIMOKADO KENTARO (JP)
SHIMOKADO KENTARO (JP)
Application Number:
PCT/JP2016/080815
Publication Date:
April 27, 2017
Filing Date:
October 18, 2016
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV (JP)
International Classes:
A61K45/00; A23L33/10; A61K8/41; A61K8/43; A61K8/44; A61K8/46; A61K8/49; A61K8/63; A61K8/64; A61K31/131; A61K31/155; A61K31/435; A61K31/4353; A61K31/444; A61K31/4458; A61K31/527; A61K31/54; A61K31/573; A61K31/7088; A61K31/713; A61K39/395; A61P17/14; A61P43/00; A61Q7/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO2001072268A1 | 2001-10-04 |
Foreign References:
| JPH07316023A | 1995-12-05 | |||
| KR20140102558A | 2014-08-22 | |||
| KR20130069019A | 2013-06-26 | |||
| US20020065222A1 | 2002-05-30 | |||
| JP2007197330A | 2007-08-09 | |||
| KR20140062249A | 2014-05-23 | |||
| KR20130040664A | 2013-04-24 | |||
| JPH10501989A | 1998-02-24 |
Other References:
SHARMA, VINOD KUMAR ET AL.: "Twice Weekly 5 mg Dexamethasone Oral Pulse in the Treatment of Extensive Alopecia Areata", THE JOURNAL OF DERMATOLOGY, vol. 26, 1999, pages 562 - 565, XP001035069, ISSN: 1346-8138
BRYANT, CLARE E. ET AL.: "Suppression by Dexamethasone of Inducible Nitric Oxide Synthase Protein Expression In Vivo A POSSIBLE ROLE FOR LIPOCORTIN 1", BIOCHEMICAL PHARMACOLOGY, vol. 55, 1998, pages 279 - 285, XP055527331, ISSN: 0006-2952
MAKOTO NODERA ET AL.: "The role of zinc in rats (6", NIPPON EISEIGAKU ZASSHI, vol. 57, no. 1, April 2002 (2002-04-01), pages 199, XP009509730, ISSN: 0021-5082
KAWANAKA, YASUFUMI ET AL.: "Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 1723 - 1743, XP055527343, ISSN: 0968-0896
BOER, RAINER ET AL.: "The Inhibitory Potency and Selectivity of Arginine Substrate Site Nitric-Oxide Synthase Inhibitors Is Solely Determined by Their Affinity toward the Different Isoenzymes", MOLECULAR PHARMACOLOGY, vol. 58, 2000, pages 1026 - 1034, XP055527351, ISSN: 0026-895X
PAIGE, JEREMY S. ET AL.: "Pharmacologic Manipulation of Nitric Oxide Signaling: Targeting NOS Dimerization and Protein-Protein Interactions", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 7, 2007, pages 97 - 114, XP055527426, ISSN: 1568-0266
MUSCARA, MARCELO N. ET AL.: "Nitric Oxide V. Therapeutic potential of nitric oxide donors and inhibitors", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 276, no. 6, 1999, pages G1313 - G1316, XP055527431, ISSN: 0193-1857
See also references of EP 3366309A4
BRYANT, CLARE E. ET AL.: "Suppression by Dexamethasone of Inducible Nitric Oxide Synthase Protein Expression In Vivo A POSSIBLE ROLE FOR LIPOCORTIN 1", BIOCHEMICAL PHARMACOLOGY, vol. 55, 1998, pages 279 - 285, XP055527331, ISSN: 0006-2952
MAKOTO NODERA ET AL.: "The role of zinc in rats (6", NIPPON EISEIGAKU ZASSHI, vol. 57, no. 1, April 2002 (2002-04-01), pages 199, XP009509730, ISSN: 0021-5082
KAWANAKA, YASUFUMI ET AL.: "Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 1723 - 1743, XP055527343, ISSN: 0968-0896
BOER, RAINER ET AL.: "The Inhibitory Potency and Selectivity of Arginine Substrate Site Nitric-Oxide Synthase Inhibitors Is Solely Determined by Their Affinity toward the Different Isoenzymes", MOLECULAR PHARMACOLOGY, vol. 58, 2000, pages 1026 - 1034, XP055527351, ISSN: 0026-895X
PAIGE, JEREMY S. ET AL.: "Pharmacologic Manipulation of Nitric Oxide Signaling: Targeting NOS Dimerization and Protein-Protein Interactions", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 7, 2007, pages 97 - 114, XP055527426, ISSN: 1568-0266
MUSCARA, MARCELO N. ET AL.: "Nitric Oxide V. Therapeutic potential of nitric oxide donors and inhibitors", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 276, no. 6, 1999, pages G1313 - G1316, XP055527431, ISSN: 0193-1857
See also references of EP 3366309A4
Attorney, Agent or Firm:
ITO, Katsuhiro et al. (JP)
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