HALOACETAMIDE AND AZIDE SUBSTITUTED COMPOUNDS AND METHODS OF USE THEREOF

WIPO Patent Application WO2005037205

A3

The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and/or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.

MILLER DUANE D (US)
NAIR VIPIN (US)
XU HUIPING (US)
DALTON JAMES T (US)

PCT/US2004/033696

January 26, 2006

October 14, 2004

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UNIV TENNESSEE RES FOUNDATION (US)
MILLER DUANE D (US)
NAIR VIPIN (US)
XU HUIPING (US)
DALTON JAMES T (US)

A61K31/165; A61K31/277; A61K31/325; A61K39/395; C07C235/24; C07C255/60; C07C271/24; C07C309/87; C07C317/40; C07C323/60; C07D207/448; C07F9/09; A61K; (IPC1-7): A61K31/505; A61K31/16; A61K31/275; A61K31/40; C07C233/05; C07C233/15; C07C255/50; C07D207/40

US6160011A	2000-12-12
US4636505A	1987-01-13

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