Title:
HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005028429
Kind Code:
A3
Abstract:
The application is directed to haloalkyl-substituted compounds of formula (I) wherein R<7> represents haloalkyl; and R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<8> are as defined in the claims. The compounds are inhibitors of cysteine proteases, in particular cathepsins B, K, L, F and S and are therefore useful in treating diseases mediated by these proteases. Pharmaceutical compositions containing these compounds and their use are also disclosed.
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Inventors:
LINK JOHN O (US)
MOSSMAN CRAIG J (US)
WOO SOON H (US)
ZIPFEL SHEILA M (US)
MOSSMAN CRAIG J (US)
WOO SOON H (US)
ZIPFEL SHEILA M (US)
Application Number:
PCT/US2004/030442
Publication Date:
May 19, 2005
Filing Date:
September 17, 2004
Export Citation:
Assignee:
AXYS PHARM INC (US)
LINK JOHN O (US)
MOSSMAN CRAIG J (US)
WOO SOON H (US)
ZIPFEL SHEILA M (US)
LINK JOHN O (US)
MOSSMAN CRAIG J (US)
WOO SOON H (US)
ZIPFEL SHEILA M (US)
International Classes:
C07C255/46; C07C317/48; C07C323/60; C07D211/66; C07D213/32; C07D231/12; C07D241/12; C07D277/30; C07D309/14; C07D333/20; C07D335/02; (IPC1-7): C07C255/46; C07C317/48; C07C323/60; C07D213/32; C07D241/12; C07D309/14; C07D333/20; C07D335/02; A61P17/06; A61P37/00; A61K31/277
Domestic Patent References:
| WO2001019796A1 | 2001-03-22 | |||
| WO2003075836A2 | 2003-09-18 | |||
| WO2001068645A2 | 2001-09-20 |
Other References:
GREENSPAN P D ET AL: "Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, 2001, pages 4524 - 4534, XP002268710, ISSN: 0022-2623
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