Title:
HALOGEN-SUBSTITUTED SACCHARIDE, METHOD FOR PRODUCING SAME, REACTION COMPOSITION OF SAME AND DEVICE FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2010/079579
Kind Code:
A1
Abstract:
Disclosed are a method for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide via a halogen-substituted saccharide synthesis reaction with the use of a subcritical fluid or a supercritical fluid as a reaction solvent, an aqueous halogen-substituted saccharide solution as a reaction composition of the same, and a production device therefor. Specifically disclosed are a method for producing a halogen-substituted saccharide which comprises using, as a reaction solvent, a subcritical fluid or a supercritical fluid at a temperature of 100 to 400oC under a pressure of 0.1 to 40 MPa or a solvent mixture prepared by mixing said fluid with an aprotic organic solvent or inorganic solvent, introducing a leaving group-substituted saccharide and the reaction solvent into a flow-type high temperature-pressure device under catalyst-free conditions, and thus selectively and continuously producing the halogen-substituted saccharide at a high yield, a high selectivity and a high speed while reducing energy expenditure and waste generation; an aqueous solution of the halogen-substituted saccharide; and a device therefor. Namely, provided are a method for continuously synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide within a short period of time, a reaction composition thereof and a synthesis device therefor.
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Inventors:
SATO MASAHIRO (JP)
KAWANAMI HAJIME (JP)
MIZUKAMI FUJIO (JP)
KAWANAMI HAJIME (JP)
MIZUKAMI FUJIO (JP)
Application Number:
PCT/JP2009/007314
Publication Date:
July 15, 2010
Filing Date:
December 25, 2009
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
SATO MASAHIRO (JP)
KAWANAMI HAJIME (JP)
MIZUKAMI FUJIO (JP)
SATO MASAHIRO (JP)
KAWANAMI HAJIME (JP)
MIZUKAMI FUJIO (JP)
International Classes:
C07H1/00; A61K51/00; B01J3/00; B01J19/00; B81B1/00; C07H5/02
Domestic Patent References:
| WO2005044833A1 | 2005-05-19 |
Foreign References:
| JPH09263594A | 1997-10-07 | |||
| JPS63218691A | 1988-09-12 | |||
| JPS63170393A | 1988-07-14 | |||
| JP2002263465A | 2002-09-17 | |||
| JPH10296076A | 1998-11-10 | |||
| JP2007268503A | 2007-10-18 |
Other References:
GERALD T. BIDE ET AL.: "The Synthesis of 2- [F-18]Fluoro-2-Deoxy-D-Glucose Using Glycals: A Reexamination", THE JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 12, 1984, pages 1327 - 1334, XP055096100
"Laboratory Chemicals and Analytical Reagents", SIGMA-ALDRICH JAPAN KABUSHIKI KAISHA, 2000, pages 644
CHI-HUEY WONG ET AL.: "Enzymatic Halohydration of Glycals", JOURNAL OF ORGANIC CHEMISTRY, vol. 57, no. 13, 1992, pages 3748 - 3750, XP055096098
CHUNG-CHENG LEE ET AL.: "Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics", SCIENCE, vol. 310, 2008, pages 1793 - 1796, XP009080110
See also references of EP 2386562A4
H.H. COENEN, V.W. PIKE, G. STOCKLIN, R. WAGNER, APPL. RADIAT. ISOTR, vol. 38, no. 8, 1987, pages 605
K. HAMACHER, H.H. COENEN, G. STOCKLIN, J. NUCL. MED., vol. 27, 1986, pages 235
C.-C. LEE, G. SUI, A. ELIZAROV, C.J. SHU, Y.-S. SHIN, A.N. DOOLEY, J. HUANG, A. DARIDON, P. WYATT, D. STOUT, SCIENCE, vol. 310, 2008, pages 1793
L.J. BROWN, D.R. BOUVET, S. CHAMPION, A.M. GIBSON, Y. HU, A. JACKSON, I. KHAN, N. MA, N. MILLOT, H. WADSWORTH, ANGEW. CHEM. INT. ED., vol. 46, 2007, pages 941
"Laboratory Chemicals and Analytical Reagents", SIGMA-ALDRICH JAPAN KABUSHIKI KAISHA, 2000, pages 644
CHI-HUEY WONG ET AL.: "Enzymatic Halohydration of Glycals", JOURNAL OF ORGANIC CHEMISTRY, vol. 57, no. 13, 1992, pages 3748 - 3750, XP055096098
CHUNG-CHENG LEE ET AL.: "Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics", SCIENCE, vol. 310, 2008, pages 1793 - 1796, XP009080110
See also references of EP 2386562A4
H.H. COENEN, V.W. PIKE, G. STOCKLIN, R. WAGNER, APPL. RADIAT. ISOTR, vol. 38, no. 8, 1987, pages 605
K. HAMACHER, H.H. COENEN, G. STOCKLIN, J. NUCL. MED., vol. 27, 1986, pages 235
C.-C. LEE, G. SUI, A. ELIZAROV, C.J. SHU, Y.-S. SHIN, A.N. DOOLEY, J. HUANG, A. DARIDON, P. WYATT, D. STOUT, SCIENCE, vol. 310, 2008, pages 1793
L.J. BROWN, D.R. BOUVET, S. CHAMPION, A.M. GIBSON, Y. HU, A. JACKSON, I. KHAN, N. MA, N. MILLOT, H. WADSWORTH, ANGEW. CHEM. INT. ED., vol. 46, 2007, pages 941
Attorney, Agent or Firm:
SUDO, MASAHIKO (JP)
Masahiko Sudo (JP)
Masahiko Sudo (JP)
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