Title:
HALOGENATED TRIPHENYLETHYLENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS
Document Type and Number:
WIPO Patent Application WO2001077057
Kind Code:
A3
Abstract:
The present invention describes novel halogenated triphenylethylene derivatives, or pharmaceutically acceptable prodrug or salt forms thereof, as selective estrogen receptor modulators for the treatment of and/or prevention of breast, uterine, ovarian, prostrate and colon cancer, osteoporosis, cardiovascular disease, and benign proliferative disorders, as well as methods for making the compounds and pharmaceutical compositions of this invention.
Inventors:
KALTENBACH ROBERT F III
TRAINOR GEORGE L
TRAINOR GEORGE L
Application Number:
PCT/US2001/011080
Publication Date:
June 13, 2002
Filing Date:
April 05, 2001
Export Citation:
Assignee:
DU PONT PHARM CO (US)
International Classes:
A61K31/201; A61P9/00; A61P13/08; A61P13/10; A61P19/10; A61P35/00; A61P9/10; A61P43/00; C07C47/24; C07C57/42; C07C57/60; C07C69/65; (IPC1-7): C07C57/60; A61K31/192; A61P13/08; A61P13/10; A61P9/00; A61P19/10
Domestic Patent References:
| WO1998009519A1 | 1998-03-12 | |||
| WO1999008682A1 | 1999-02-25 |
Foreign References:
| US5681835A | 1997-10-28 |
Other References:
WILLSON T M ET AL: "3-U4-(1,2-DIPHENYLBUT-1-ENYL)PHENYLACRYLIC ACID: A NON-STEROIDAL ESTROGEN WITH FUCNTIONAL SLECTIVITY FOR BONE OVER UTERUS IN RATS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 37, no. 11, 25 May 1994 (1994-05-25), pages 1550 - 1552, XP002057515, ISSN: 0022-2623
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