Title:
HCV NS-3 SERINE PROTEASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005073195
Kind Code:
A3
Abstract:
Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
Inventors:
ROSENQUIST AASA (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
SAMUELSSON BERTIL (SE)
WALLBERG HANS (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
SAMUELSSON BERTIL (SE)
WALLBERG HANS (SE)
Application Number:
PCT/SE2005/000097
Publication Date:
September 29, 2005
Filing Date:
January 28, 2005
Export Citation:
Assignee:
MEDIVIR AB (SE)
ROSENQUIST AASA (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
SAMUELSSON BERTIL (SE)
WALLBERG HANS (SE)
ROSENQUIST AASA (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
SAMUELSSON BERTIL (SE)
WALLBERG HANS (SE)
International Classes:
C07C235/40; C07C237/04; C07C237/10; C07C247/04; C07C271/22; C07C281/02; C07C309/73; C07C311/51; C07D207/16; C07D215/233; C07D245/04; C07D401/12; C07D405/14; C07D409/14; C07D413/14; C07D417/04; C07D417/14; C07D487/04; C07K5/02; C07K5/06; C07D215/22; C07D; (IPC1-7): C07K5/02; A61K31/47; A61P31/12; C07D487/04; C07D401/12; C07D245/04; C07D417/14
Domestic Patent References:
| WO2000059929A1 | 2000-10-12 |
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