Title:
HEART FAILURE DETECTION METHOD, INSTRUMENT FOR HEART FAILURE DETECTION, SANDWICH IMMUNOASSAY METHOD, AND ANTIBODY COMBINATION
Document Type and Number:
WIPO Patent Application WO/2019/198822
Kind Code:
A1
Abstract:
[Problem] To provide a means for detecting heart failure more easily and with higher accuracy. [Solution] A heart failure detection method using a sample collected from an organism, wherein heart failure is detected by conducting sandwich immunoassay of NT-proANP contained in the sample using a first antibody for capturing, for which the epitope is any site from among positions 31–67 of the amino acid sequence of the NT-proANP, and a second antibody for labeling, for which the epitope is any site from among positions 31–67 of the amino acid sequence of the NT-proANP. Since both of the epitopes for the two types of antibodies for capturing and labeling are among positions 31–67 of the amino acid sequence of the NT-proANP, even in cases in which the NT-proANP is further divided into three fragments in the blood stream, it is possible to detect the same amount of material as the NT-proANP, and thus it is possible to detect heart failure easily and with high accuracy.
Inventors:
UDA TOMOHIKO (JP)
KITAYAMA SAEKO (JP)
ISHII KENYO (JP)
KITAYAMA SAEKO (JP)
ISHII KENYO (JP)
Application Number:
PCT/JP2019/015992
Publication Date:
October 17, 2019
Filing Date:
April 12, 2019
Export Citation:
Assignee:
KYORITSU SEIYAKU CORP (JP)
International Classes:
G01N33/53; G01N33/543; G01N33/68; C07K16/18
Foreign References:
| JP2014210761A | 2014-11-13 | |||
| JP5675346B2 | 2015-02-25 | |||
| JPH08226919A | 1996-09-03 | |||
| JP2006523298W | ||||
| JP2014210761A | 2014-11-13 |
Other References:
SREEDEVI DAGGUBATI , JAMES R PARKS , ROSE M OVERTON , GUILLERMO CINTRON , DOUGLAS D SCHOCKEN , DAVIS L VESELY : "Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators", CARDIOVASCULAR RESEARCH, vol. 36, 30 November 1997 (1997-11-30), pages 246 - 255, XP000913576, ISSN: 0008-6363, DOI: 10.1016/S0008-6363(97)00164-8
BOSWOOD A; ATTREE S; PAGE K: "Clinical validation of a proANP 31-67 fragment ELISA in the diagnosis of heart failure in the dog", JOURNAL OF SMALL ANIMAL PRACTICE, vol. 44, no. 3, 31 March 2003 (2003-03-31), pages 104 - 108, XP055149200, ISSN: 0022-4510, DOI: 10.1111/j.1748-5827.2003.tb00128.x
HAGGSTROM; HANSSON J; KVART K; PEDERSEN C; VUOLTEENAHO H D; OLSSON O; K: "Relationship between different natriuretic peptides and severity of naturally acquired mitral regurgitation in dogs with chronic myxomatous valve disease", JOURNAL OF VETERINARY CARDIOLOGY, vol. 2, no. 1, May 2000 (2000-05-01), pages 7 - 16, XP005287731, ISSN: 1760-2734, DOI: 10.1016/S1760-2734(06)70002-9
YASUTOMO HORI, SHIGEKI YAMANO; KAZUTAKA KANAI; FUMIO HOSHI, NAOYUKI ITOH, SEI-ICHI HIGUCHI: "Clinical implications of measurement of plasma atrial natriuretic peptide concentration in dogs with spontaneous heart disease", JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, vol. 239, no. 8, 15 October 2011 (2011-10-15), pages 1077 - 1083, XP009524368, ISSN: 0003-1488, DOI: 10.2460/javma.239.8.1077
SREEDEVI DAGGUBATI , JAMES R PARKS , ROSE M OVERTON , GUILLERMO CINTRON , DOUGLAS D SCHOCKEN , DAVIS L VESELY : "Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators", CARDIOVASCULAR RESEARCH, vol. 36, 30 November 1997 (1997-11-30), pages 246 - 255, XP000913576, ISSN: 0008-6363, DOI: 10.1016/S0008-6363(97)00164-8
BOSWOOD A; ATTREE S; PAGE K: "Clinical validation of a proANP 31-67 fragment ELISA in the diagnosis of heart failure in the dog", JOURNAL OF SMALL ANIMAL PRACTICE, vol. 44, no. 3, 31 March 2003 (2003-03-31), pages 104 - 108, XP055149200, ISSN: 0022-4510, DOI: 10.1111/j.1748-5827.2003.tb00128.x
HAGGSTROM; HANSSON J; KVART K; PEDERSEN C; VUOLTEENAHO H D; OLSSON O; K: "Relationship between different natriuretic peptides and severity of naturally acquired mitral regurgitation in dogs with chronic myxomatous valve disease", JOURNAL OF VETERINARY CARDIOLOGY, vol. 2, no. 1, May 2000 (2000-05-01), pages 7 - 16, XP005287731, ISSN: 1760-2734, DOI: 10.1016/S1760-2734(06)70002-9
YASUTOMO HORI, SHIGEKI YAMANO; KAZUTAKA KANAI; FUMIO HOSHI, NAOYUKI ITOH, SEI-ICHI HIGUCHI: "Clinical implications of measurement of plasma atrial natriuretic peptide concentration in dogs with spontaneous heart disease", JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, vol. 239, no. 8, 15 October 2011 (2011-10-15), pages 1077 - 1083, XP009524368, ISSN: 0003-1488, DOI: 10.2460/javma.239.8.1077
SREEDEVI DAGGUBATI , JAMES R PARKS , ROSE M OVERTON , GUILLERMO CINTRON , DOUGLAS D SCHOCKEN , DAVIS L VESELY : "Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators", CARDIOVASCULAR RESEARCH, vol. 36, 30 November 1997 (1997-11-30), pages 246 - 255, XP000913576, ISSN: 0008-6363, DOI: 10.1016/S0008-6363(97)00164-8
Attorney, Agent or Firm:
NIWA Shunsuke (JP)
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