Title:
HEART TISSUE SIMULATING SHEET FOR HEART TRANSPLANTS, CONTAINING ADIPOSE STEM CELL SHEET, AND MANUFACTURING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/130312
Kind Code:
A1
Abstract:
The present invention relates to a heart simulating sheet for heart transplants, and a manufacturing method therefor, the sheet comprising: a sheet comprising adipose stem cells; heart myocytes; and fibroblasts. The heart simulating sheet for heart transplants, having a cell structure similar to that of the heart, according to the present invention, exhibits a high engraftment rate and a transplanted cell proliferation ability during transplantation to a damaged heart site, thereby being effectively usable in the treatment of heart diseases.
Inventors:
LIM DO-SUN (KR)
KIM JONG-HO (KR)
JOO HYUNG JOON (KR)
KIM JONG-HO (KR)
JOO HYUNG JOON (KR)
Application Number:
PCT/KR2019/013481
Publication Date:
June 25, 2020
Filing Date:
October 15, 2019
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61L27/38; C12N5/077; C12N5/0775
Foreign References:
| KR101586839B1 | 2016-01-19 | |||
| KR20170023188A | 2017-03-02 | |||
| JP2017101015A | 2017-06-08 |
Other References:
MATSUURA, K.: "Creation of mouse embryonic stem cell -derived cardiac cell sheets", BIOMATERIALS, 2011, pages 7355 - 7362, XP028261564
OTSUKI, Y.: "Adipose stem cell sheets improved cardiac function in the rat myocardial infarction, but did not alter cardiac contractile responses to 13-adrenergic stimulation", BIOMEDICAL RESEARCH, 2015, Tokyo, pages 11 - 19, XP055721206
OTSUKI, Y.: "Adipose stem cell sheets improved cardiac function in the rat myocardial infarction, but did not alter cardiac contractile responses to 13-adrenergic stimulation", BIOMEDICAL RESEARCH, 2015, Tokyo, pages 11 - 19, XP055721206
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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