Title:
HEAT SHOCK PROTEIN EXPRESSION INDUCER
Document Type and Number:
WIPO Patent Application WO/2012/043808
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a heat shock protein expression inducer capable of inducing the in-vivo expression of HSP; food, drink, a pharmaceutical product, and a cosmetic containing the HSP expression inducer; and an HSP expression inducing method. Compounds derived from a specific plant such as Zerumbone or an analogue thereof exert an excellent action of inducing the expression of heat shock proteins in vivo, and can be used as the active ingredient for a heat shock protein expression inducer.
Inventors:
IKEDA YASUTAKA (JP)
IRIE KAZUHIRO (JP)
OHNISHI KOHTA (JP)
MURAKAMI AKIRA (JP)
IRIE KAZUHIRO (JP)
OHNISHI KOHTA (JP)
MURAKAMI AKIRA (JP)
Application Number:
PCT/JP2011/072592
Publication Date:
April 05, 2012
Filing Date:
September 30, 2011
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
IKEDA YASUTAKA (JP)
IRIE KAZUHIRO (JP)
OHNISHI KOHTA (JP)
MURAKAMI AKIRA (JP)
IKEDA YASUTAKA (JP)
IRIE KAZUHIRO (JP)
OHNISHI KOHTA (JP)
MURAKAMI AKIRA (JP)
International Classes:
A61K31/122; A23L1/30; A61K8/35; A61K8/36; A61K8/46; A61K8/67; A61K8/97; A61K31/047; A61K31/07; A61K31/19; A61K31/26; A61K36/00; A61P3/02; A61P3/10; A61P9/00; A61P19/02; A61P21/00; A61P21/02; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P37/04; A61Q19/00; C12N15/09
Foreign References:
| JP2003070442A | 2003-03-11 | |||
| JPH10330243A | 1998-12-15 |
Other References:
HISASHI MATSUDA, ET AL.: "Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: Structure requirement and role of heat shock protein induction", LIFE SCIENCES, vol. 66, no. 22, 21 April 2000 (2000-04-21), pages 2151 - 2157
MURAKAMI; A; ET AL: "Zerumbone, a southeast Asian giner sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The alpha,beta-unsaturated carbonyl group is a prerequisite", CARCINOGENESIS, vol. 23, no. 5, 2002, pages 795 - 802, XP008101002
YASUNARI TAKADA, AKIRA MURAKAMI AND BHARAT B AGGARWAL: "Zerumbone abolishes NF-B and IB kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion", ONCOGENE, vol. 24, 2005, pages 6957 - 6969, XP008100998, DOI: doi:l0.1038/sj.onc.1208845
HYE-YOUNG MIN, ET AL.: "Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 9, no. 7-8, July 2009 (2009-07-01), pages 844 - 849
MURAKAMI; A; ET AL: "Zerumbone, a southeast Asian giner sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The alpha,beta-unsaturated carbonyl group is a prerequisite", CARCINOGENESIS, vol. 23, no. 5, 2002, pages 795 - 802, XP008101002
YASUNARI TAKADA, AKIRA MURAKAMI AND BHARAT B AGGARWAL: "Zerumbone abolishes NF-B and IB kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion", ONCOGENE, vol. 24, 2005, pages 6957 - 6969, XP008100998, DOI: doi:l0.1038/sj.onc.1208845
HYE-YOUNG MIN, ET AL.: "Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 9, no. 7-8, July 2009 (2009-07-01), pages 844 - 849
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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Claims: