Title:
HEAT SHOCK PROTEIN EXPRESSION INDUCERS
Document Type and Number:
WIPO Patent Application WO/2000/018390
Kind Code:
A1
Abstract:
A heat shock protein expression inducer containing as the active ingredient a chalcone derivative; another heat shock protein expression inducer which can be selected by a screening method involving the step of using a cell line which has been transformed by a vector carrying a reporter gene ligated to the downstream of a heat shock protein gene promoter and examining the induction of the expression of the reporter gene product in the presence of a test compound; and remedies or preventives for ischemic diseases, wound or ulcer containing either of the above-described heat shock protein expression inducers.
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Inventors:
MATSUMOTO SHUJI (JP)
KOJIMA ATSUYUKI (JP)
YANAGI HIDEKI (JP)
YURA TAKASHI (JP)
KOJIMA ATSUYUKI (JP)
YANAGI HIDEKI (JP)
YURA TAKASHI (JP)
Application Number:
PCT/JP1999/005268
Publication Date:
April 06, 2000
Filing Date:
September 28, 1999
Export Citation:
Assignee:
HSP KENKYUSHO KK (JP)
MATSUMOTO SHUJI (JP)
KOJIMA ATSUYUKI (JP)
YANAGI HIDEKI (JP)
YURA TAKASHI (JP)
MATSUMOTO SHUJI (JP)
KOJIMA ATSUYUKI (JP)
YANAGI HIDEKI (JP)
YURA TAKASHI (JP)
International Classes:
C07C225/16; C07C225/22; C07C233/33; C07C235/84; C07C311/08; (IPC1-7): A61K31/12; A61K31/136; A61K31/166; A61K31/167; A61K31/18; A61K31/222
Foreign References:
| US5489614A | 1996-02-06 |
Other References:
WIEGANT F. A. C. ET AL.: "Stressor-specific Induction of Heat Shock Proteins in Rat Hepatoma Cells", TOXICOLOGY, vol. 94, no. 1-3, 1994, pages 143 - 159, XP002925829
Attorney, Agent or Firm:
Hosoda, Yoshinori (Tanimachi 2-chome Chuo-ku, Osaka-shi Osaka, JP)
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