Title:
HELICASE-PRIMASE INHIBITORS FOR USE IN A METHOD OF TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2014/124978
Kind Code:
A3
Abstract:
The present invention relates to the use of helicase-primase inhibitors in a method of treating Alzheimer's Disease (AD). Particularly, the present invention relates to the use of helicase-primase inhibitors in a method of treating AD in a subject that is having HSV-1 infection and is having AD or is having HSV-1 infection and is suspected of having AD. The provided antiviral helicase-primase inhibitors affect the accumulation of the key AD proteins amyloid beta and abnormally phosphorylated tau that occur during HSV-1 infection.
Inventors:
ITZHAKI RUTH (GB)
Application Number:
PCT/EP2014/052743
Publication Date:
October 30, 2014
Filing Date:
February 12, 2014
Export Citation:
Assignee:
AICURIS GMBH & CO KG (DE)
International Classes:
A61K31/427; A61K31/426; A61P25/28
Domestic Patent References:
| WO2001047904A1 | 2001-07-05 | |||
| WO2006103011A1 | 2006-10-05 | |||
| WO2013045491A1 | 2013-04-04 |
Other References:
WOZNIAK M.A.; ITZHAKI R.F.: "Antiviral agents in Alzheimer's disease: hope for thefuture?", THERAP. ADV. IN NEUROL. DISORDERS, 2010, XP002696117
Attorney, Agent or Firm:
BOEHMERT & BOEHMERT ANWALTSPARTNERSCHAFT MBB PATENTANWÄLTE RECHTSANWÄLTE (Bremen, DE)
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