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Title:
HEMIASTERLIN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2019/031615
Kind Code:
A1
Abstract:
Compounds represented by formula (1) or salts thereof. [In the formula, AA represents a specific amino acid residue or a C1–6 alkyl ester thereof, each AA being the same or different and the AAs being linked by an amide linkage when there are multiple AAs, and the N-terminal nitrogen atom of (AA)m forming an amide linkage with carbonyl (a), Q represents an unsubstituted phenyl group or a group represented by formula (Q-1), formula (Qa-2), formula (Qa-3), formula (Qa-4), formula (Qa-5), formula (Qa-6), or formula (Qa-7), R1a and R1b each independently represent a hydrogen atom or a C1–6 alkyl group, and m represents an integer from 1 to 10.]

Inventors:
BAN Hitoshi (1-98, Kasugadenaka 3-chome, Konohana-ku, Osaka-sh, Osaka 22, 〒5540022, JP)
NISHIO Yukihiro (9-1-820, Inari 1-chome Fujisawa-sh, Kanagawa 62, 〒2510862, JP)
SUWA Atsushi (1-98, Kasugadenaka 3-chome, Konohana-ku, Osaka-sh, Osaka 22, 〒5540022, JP)
Application Number:
JP2018/030144
Publication Date:
February 14, 2019
Filing Date:
August 10, 2018
Export Citation:
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Assignee:
SUMITOMO DAINIPPON PHARMA CO., LTD. (6-8 Dosho-machi 2-chome, Chuo-ku Osaka-sh, Osaka 24, 〒5418524, JP)
International Classes:
C07K5/065; A61K38/06; A61K38/08; A61K39/395; A61K45/00; A61K47/68; A61P35/00; A61P43/00; C07K5/072; C07K5/093; C07K16/28
Domestic Patent References:
WO2015151079A22015-10-08
WO2014057436A22014-04-17
Foreign References:
JPH11505211A1999-05-18
JP2016516063A2016-06-02
JP2011500725A2011-01-06
JP2012522513A2012-09-27
JP2017506234A2017-03-02
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (SOEI PATENT AND LAW FIRM, Marunouchi MY PLAZA 9th fl. 1-1, Marunouchi 2-chome, Chiyoda-k, Tokyo 05, 〒1000005, JP)
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