Title:
HEMIASTERLIN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2019/031615
Kind Code:
A1
Abstract:
Compounds represented by formula (1) or salts thereof. [In the formula, AA represents a specific amino acid residue or a C1–6 alkyl ester thereof, each AA being the same or different and the AAs being linked by an amide linkage when there are multiple AAs, and the N-terminal nitrogen atom of (AA)m forming an amide linkage with carbonyl (a), Q represents an unsubstituted phenyl group or a group represented by formula (Q-1), formula (Qa-2), formula (Qa-3), formula (Qa-4), formula (Qa-5), formula (Qa-6), or formula (Qa-7), R1a and R1b each independently represent a hydrogen atom or a C1–6 alkyl group, and m represents an integer from 1 to 10.]
Inventors:
BAN HITOSHI (JP)
NISHIO YUKIHIRO (JP)
SUWA ATSUSHI (JP)
NISHIO YUKIHIRO (JP)
SUWA ATSUSHI (JP)
Application Number:
PCT/JP2018/030144
Publication Date:
February 14, 2019
Filing Date:
August 10, 2018
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07K5/065; A61K38/06; A61K38/08; A61K39/395; A61K45/00; A61K47/68; A61P35/00; A61P43/00; C07K5/072; C07K5/093; C07K16/28
Domestic Patent References:
WO2015151079A2 | 2015-10-08 | |||
WO2014057436A2 | 2014-04-17 | |||
WO2004026293A2 | 2004-04-01 | |||
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DUBOWCHIK G. M. ET AL., BIOORG. MED. CHEM. LETT., vol. 8, 1998, pages 3341 - 3346
DANDO M. P. ET AL., BIOCHEM. J., vol. 339, 1999, pages 743 - 749
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THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
J. MED. CHEM., vol. 50, 2007, pages 4329 - 4339
TETRAHEDRON LETT., vol. 38, 1997, pages 317 - 320
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ORG. LETT., vol. 4, 2002, pages 695 - 697
J. ORG. CHEM., vol. 66, 2001, pages 7355 - 7364
TETRAHEDRON LETT., vol. 45, 2004, pages 495 - 499
BIOCONJUGATE CHEM., vol. 13, 2002, pages 855 - 869
BIOCONJUGATE CHEM., vol. 26, 2015, pages 650 - 659
MOLECULES, vol. 20, no. 6, 2015, pages 10004 - 10031
NOBUO IZUMIYATETSUO KATOHARUHIKO AOYAGIMICHINORI WAKI: "Fundamentals and Experiments of Peptide Synthesis", 1985, MARUZEN CO., LTD.
BIOORG. MED. CHEM. LETT., vol. 14, no. 21, 1 November 2004 (2004-11-01), pages 5317 - 22
J. MED. CHEM., vol. 47, no. 19, 9 September 2004 (2004-09-09), pages 4774 - 86
J. MED. CHEM., vol. 49, 2006, pages 4392 - 4408
"Antibody Drug Conjugates, Methods in Molecular Biology", vol. 1045, 2013, pages: 267 - 284
HAMBLETT K. J. ET AL., CLIN. CANCER RES., vol. 10, 2004, pages 7063 - 7070
"New Edition Toxicology", 2009, ASAKURA PUBLISHING CO., LTD.
See also references of EP 3666788A4
ZASK, A., BIOORG. MED. CHEM.LETT., vol. 14, 2004, pages 4353 - 4358
ZASK, A., J. MED. CHEM., vol. 47, 2004, pages 4774 - 4786
YAMASHITA, A., BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5317 - 5322
NIEMAN, J. A., J, NAT. PROD., vol. 66, 2003, pages 183 - 199
ROCHA-LIMA, C.M., CANCER, vol. 118, 2012, pages 4262 - 4270
TOKI, J. ORG. CHEM., vol. 67, 2002, pages 1866 - 1872
DUBOWCHIK G. M. ET AL., BIOORG. MED. CHEM. LETT., vol. 8, 1998, pages 3341 - 3346
DANDO M. P. ET AL., BIOCHEM. J., vol. 339, 1999, pages 743 - 749
MOL. CANCER THER., vol. 14, 2015, pages 1614 - 1624
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
J. MED. CHEM., vol. 50, 2007, pages 4329 - 4339
TETRAHEDRON LETT., vol. 38, 1997, pages 317 - 320
J. NAT. PROD., vol. 66, 2003, pages 183 - 199
ORG. LETT., vol. 4, 2002, pages 695 - 697
J. ORG. CHEM., vol. 66, 2001, pages 7355 - 7364
TETRAHEDRON LETT., vol. 45, 2004, pages 495 - 499
BIOCONJUGATE CHEM., vol. 13, 2002, pages 855 - 869
BIOCONJUGATE CHEM., vol. 26, 2015, pages 650 - 659
MOLECULES, vol. 20, no. 6, 2015, pages 10004 - 10031
NOBUO IZUMIYATETSUO KATOHARUHIKO AOYAGIMICHINORI WAKI: "Fundamentals and Experiments of Peptide Synthesis", 1985, MARUZEN CO., LTD.
BIOORG. MED. CHEM. LETT., vol. 14, no. 21, 1 November 2004 (2004-11-01), pages 5317 - 22
J. MED. CHEM., vol. 47, no. 19, 9 September 2004 (2004-09-09), pages 4774 - 86
J. MED. CHEM., vol. 49, 2006, pages 4392 - 4408
"Antibody Drug Conjugates, Methods in Molecular Biology", vol. 1045, 2013, pages: 267 - 284
HAMBLETT K. J. ET AL., CLIN. CANCER RES., vol. 10, 2004, pages 7063 - 7070
"New Edition Toxicology", 2009, ASAKURA PUBLISHING CO., LTD.
See also references of EP 3666788A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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