HEMIOXALATE SALT OF CRYSTALLINE O-DESMETHYLVENLAFAXINE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF

WIPO Patent Application WO/2011/155797

A3

The present invention relates to hemioxalate of crystalline O-desmethylvenlafaxine which maximizes solubility and has physicochemical properties of a solid material which is pharmaceutically preferable due to its non-hygroscopicity, to a preparation method of the hemioxalate, and to a pharmaceutical composition of the hemioxalate. The hemioxalate of crystalline O-desmethylvenlafaxine according to the present invention can: increase bioavailability of drugs due to its high solubility; allow various formulations to be very easily designed without composition size limitations; and administer high doses of drugs regardless of the dose-limiting volume of an animal. Thus, the hemioxalate of crystalline O-desmethylvenlafaxine facilitates the confirmation of expressible toxicity, and is suitable for distribution of raw materials and production of medicines because of low hygroscopicity.

PARK SANG-GOOK (KR)
LIM JOONG-IN (KR)
HAN SANG-DUG (KR)
MIN JONG-PIL (KR)
KIM JEONG-HOON (KR)
JANG SUN-WOO (KR)
HWANG HYUNG-DON (KR)
KIM SOON-HOE (KR)

PCT/KR2011/004284

May 03, 2012

June 10, 2011

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DONG A PHARM CO LTD (KR)
PARK SANG-GOOK (KR)
LIM JOONG-IN (KR)
HAN SANG-DUG (KR)
MIN JONG-PIL (KR)
KIM JEONG-HOON (KR)
JANG SUN-WOO (KR)
HWANG HYUNG-DON (KR)
KIM SOON-HOE (KR)

C07C215/64; A61K31/135; A61P25/24; C07C55/06

WO2010008735A2

2010-01-21

EP2119695A1	2009-11-18
KR20100015923A	2010-02-12

ROH, Jae-Chull (4F. Halla Building, 641-17,Yeoksam-dong, Gangnam-gu, Seoul 135-909, KR)

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