Title:
HEPARIN-POLYPEPTIDE DUAL GRAFTED CYCLODEXTRIN SKELETON COMPOSITION WITH LUNG TARGETING, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/068927
Kind Code:
A1
Abstract:
A low molecular heparin-polypeptide-crosslinked cyclodextrin organic skeleton (LMW H-polypeptide-COF) composition with lung targeting and a preparation method therefor. Also disclosed are a drug-carrying LMWH-polypeptide-COF composition carrying a drug, which comprises an LMWH-polypeptide-COF composition, and an anti-tumor drug or a drug targeting the lungs. Further disclosed is a pharmaceutical composition, which comprises a drug-carrying LMWH-polypeptide-COF composition and a pharmaceutically acceptable carrier. The composition can be targeted at treating tumors, particularly lung cancer.
Inventors:
ZHANG JIWEN (CN)
HE YAPING (CN)
XIONG TING (CN)
WU LI (CN)
HE SIYU (CN)
ZHOU YONG (CN)
ZHOU PANPAN (CN)
CHEN JIACAI (CN)
HE YAPING (CN)
XIONG TING (CN)
WU LI (CN)
HE SIYU (CN)
ZHOU YONG (CN)
ZHOU PANPAN (CN)
CHEN JIACAI (CN)
Application Number:
PCT/CN2021/122163
Publication Date:
April 07, 2022
Filing Date:
September 30, 2021
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K47/50; A61K9/00; A61K47/36; A61K47/40; A61K47/42; A61P35/00; C08B37/10; C08B37/16; C08G81/00
Foreign References:
| CN111440253A | 2020-07-24 | |||
| US20190314555A1 | 2019-10-17 |
Other References:
WANG, JIANGUO: "Study on the Multi-targeted Nanoparticles for Tumor Antiangiogenesis", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 17 April 2019 (2019-04-17), pages 1 - 64, XP055917893
CHUNYU XIA ET AL.: "Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment", THERANOSTICS, vol. 9, no. 2, 1 January 2019 (2019-01-01), XP055917894, ISSN: 1838-7640
WANG FEN, LI YUANYUAN, SHEN YINGQIANG, WANG ANMING, WANG SHULING, XIE TIAN: "The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 14, no. 7, 1 January 2013 (2013-01-01), pages 13447 - 13462, XP055917895, DOI: 10.3390/ijms140713447
CHUNYU XIA ET AL.: "Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment", THERANOSTICS, vol. 9, no. 2, 1 January 2019 (2019-01-01), XP055917894, ISSN: 1838-7640
WANG FEN, LI YUANYUAN, SHEN YINGQIANG, WANG ANMING, WANG SHULING, XIE TIAN: "The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 14, no. 7, 1 January 2013 (2013-01-01), pages 13447 - 13462, XP055917895, DOI: 10.3390/ijms140713447
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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