Title:
HEPATIC FIBROSIS-AMELIORATING AGENT
Document Type and Number:
WIPO Patent Application WO/2016/139740
Kind Code:
A1
Abstract:
[Problem] To verify an advantage in terms of hepatic fibrosis-ameliorating effect in hepatitis/hepatic cirrhosis using a thioacetamide hepatic dysfunction model, and provide this advantage. [Solution] This advantage is achieved by means of a compounding agent that includes zinc and selenium.
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Inventors:
KUBOTA SATORU (JP)
KONO TORU (JP)
KONO TORU (JP)
Application Number:
PCT/JP2015/056147
Publication Date:
September 09, 2016
Filing Date:
March 03, 2015
Export Citation:
Assignee:
MEDICO CONSL CO LTD (JP)
International Classes:
A61K33/30; A61K33/04; A61K47/02; A61K47/22; A61P1/16
Other References:
TORU KONO ET AL.: "Aen Selenium Fukugo Eiyo Kino Shokuhin ni yoru Kan Sen'ika Yokusei Koka ni Tsuite no Dobutsu Model deno Kento", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2013, 5 March 2013 (2013-03-05), pages 2A16 p04
TAKASHI HIMOTO ET AL.: "Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease", NUTRITION RESEARCH, vol. 31, 2011, pages 829 - 835, XP028597906, DOI: doi:10.1016/j.nutres.2011.09.021
TAKASHI HIMOTO ET AL.: "Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease", SCAND J GASTROENTEROL., vol. 42, 2007, pages 1078 - 1087
TAKASHI HIMOTO ET AL.: "Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease", NUTRITION RESEARCH, vol. 31, 2011, pages 829 - 835, XP028597906, DOI: doi:10.1016/j.nutres.2011.09.021
TAKASHI HIMOTO ET AL.: "Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease", SCAND J GASTROENTEROL., vol. 42, 2007, pages 1078 - 1087
Attorney, Agent or Firm:
MIYAZAKI, Tadaaki et al. (JP)
Miyazaki Tadaaki (JP)
Miyazaki Tadaaki (JP)
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