Title:
HEPATIC FIBROSIS CHIP AND USE THEREOF IN DEVELOPMENT AND TREATMENT OF HEPATIC FIBROSIS DRUG
Document Type and Number:
WIPO Patent Application WO/2023/206763
Kind Code:
A1
Abstract:
A hepatic fibrosis chip, at least comprising an upper-layer substrate and a lower-layer substrate which are tightly attached. A cell culture area is arranged on the lower-layer substrate, and is divided into at least three culture areas. The at least three culture areas are communicated with each other and are used for culturing different types of hepatocytes, respectively. The hepatocytes comprise Kupffer cells, liver sinusoidal endothelial cells, hepatic stellate cells, and parenchymal hepatic cells. The hepatocytes are cells or cell lines formed by transforming primary cells and stem cells. The upper-layer substrate is provided with a micro-channel corresponding to each culture area, which is used for supplying nutrients or stimulants to the corresponding culture area.
Inventors:
ZHANG XIULI (CN)
JI ZHENNI (CN)
LUO YONG (CN)
JI ZHENNI (CN)
LUO YONG (CN)
Application Number:
PCT/CN2022/100865
Publication Date:
November 02, 2023
Filing Date:
June 23, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C12M3/00; C12N5/071
Foreign References:
| CN109456890A | 2019-03-12 | |||
| CN111218404A | 2020-06-02 | |||
| US20130236972A1 | 2013-09-12 | |||
| CN109880791A | 2019-06-14 | |||
| CN108277198A | 2018-07-13 | |||
| CN109337860A | 2019-02-15 | |||
| CN112280678A | 2021-01-29 |
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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