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Title:
HEPATITIS B VACCINE COMPOSITION FOR NASAL ADMINISTRATION AND NASAL ADMINISTRATION SYSTEM THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/048570
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a vaccine composition for nasal administration that is usable for preventing and treating hepatitis B, and a nasal administration system of the vaccine. Provided is a hepatitis B vaccine composition that comprises: (i) virus-like particles containing hepatitis B surface L antigen proteins (HBs-L antigen proteins) of two or more genotypes selected from the group consisting of types A, B, C and D, and a hepatitis B nucleocapsid antigen (HBc antigen) protein; and (ii) a base material containing a carboxyvinyl polymer having been treated by externally applying a shear force. Also provided is a nasal administration system of the hepatitis B vaccine, said system comprising the composition filled into a sprayable device equipped with a nasal spray nozzle.

Inventors:
HIASA YOICHI (JP)
YOSHIDA OSAMU (JP)
KOHARA MICHINORI (JP)
KOHARA KYOKO (JP)
GOH YASUMASA (JP)
ODA YASUNORI (JP)
KAMISHITA TAIZOU (JP)
MIYAZAKI TAKASHI (JP)
Application Number:
PCT/JP2023/031188
Publication Date:
March 07, 2024
Filing Date:
August 29, 2023
Export Citation:
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Assignee:
UNIV NAT CORP EHIME UNIV (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
UNIV KAGOSHIMA (JP)
BEACLE INC (JP)
TOKO YAKUHIN KOGYO KK (JP)
International Classes:
A61K39/29; A61K9/12; A61K39/295; A61K47/32; A61M11/00; A61P31/20; C07K14/02; C07K19/00; C12N7/01
Domestic Patent References:
WO2019070019A12019-04-11
WO2018225731A12018-12-13
Other References:
SANADA TAKAHIRO; YAMAMOTO NAOKI; KAYESH MOHAMMAD ENAMUL HOQUE; TSUKIYAMA-KOHARA KYOKO; HASEGAWA HIDEKI; MIYAZAKI TAKASHI; TAKANO J: "Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 520, no. 1, 30 September 2019 (2019-09-30), Amsterdam NL , pages 86 - 92, XP085867964, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.09.072
SANADA, TAKAHIRO; KAYESH, MOHAMMAD; HASEGAWA, HIDEKI; HIASA, YOICHI; GOH, YASUMASA; MIYAZAKI, TAKASHI; KOHARA, MICHINORI: "HBS-Large Hybrid Protein Vaccination Via Intranasal Route with Carboxyl Vinyl Polymer Rapidly Induced Strong Neutralizing Antibody and Anti-HBS IgA", HEPATOLOGY, vol. 70, no. S1, 1 January 2019 (2019-01-01), US , pages 605A, XP009553573, ISSN: 0270-9139
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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