Title:
HEPATITIS B VACCINE COMPOSITION FOR NASAL ADMINISTRATION AND NASAL ADMINISTRATION SYSTEM THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/048570
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a vaccine composition for nasal administration that is usable for preventing and treating hepatitis B, and a nasal administration system of the vaccine. Provided is a hepatitis B vaccine composition that comprises: (i) virus-like particles containing hepatitis B surface L antigen proteins (HBs-L antigen proteins) of two or more genotypes selected from the group consisting of types A, B, C and D, and a hepatitis B nucleocapsid antigen (HBc antigen) protein; and (ii) a base material containing a carboxyvinyl polymer having been treated by externally applying a shear force. Also provided is a nasal administration system of the hepatitis B vaccine, said system comprising the composition filled into a sprayable device equipped with a nasal spray nozzle.
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Inventors:
HIASA YOICHI (JP)
YOSHIDA OSAMU (JP)
KOHARA MICHINORI (JP)
KOHARA KYOKO (JP)
GOH YASUMASA (JP)
ODA YASUNORI (JP)
KAMISHITA TAIZOU (JP)
MIYAZAKI TAKASHI (JP)
YOSHIDA OSAMU (JP)
KOHARA MICHINORI (JP)
KOHARA KYOKO (JP)
GOH YASUMASA (JP)
ODA YASUNORI (JP)
KAMISHITA TAIZOU (JP)
MIYAZAKI TAKASHI (JP)
Application Number:
PCT/JP2023/031188
Publication Date:
March 07, 2024
Filing Date:
August 29, 2023
Export Citation:
Assignee:
UNIV NAT CORP EHIME UNIV (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
UNIV KAGOSHIMA (JP)
BEACLE INC (JP)
TOKO YAKUHIN KOGYO KK (JP)
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
UNIV KAGOSHIMA (JP)
BEACLE INC (JP)
TOKO YAKUHIN KOGYO KK (JP)
International Classes:
A61K39/29; A61K9/12; A61K39/295; A61K47/32; A61M11/00; A61P31/20; C07K14/02; C07K19/00; C12N7/01
Domestic Patent References:
WO2019070019A1 | 2019-04-11 | |||
WO2018225731A1 | 2018-12-13 |
Other References:
SANADA TAKAHIRO; YAMAMOTO NAOKI; KAYESH MOHAMMAD ENAMUL HOQUE; TSUKIYAMA-KOHARA KYOKO; HASEGAWA HIDEKI; MIYAZAKI TAKASHI; TAKANO J: "Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 520, no. 1, 30 September 2019 (2019-09-30), Amsterdam NL , pages 86 - 92, XP085867964, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.09.072
SANADA, TAKAHIRO; KAYESH, MOHAMMAD; HASEGAWA, HIDEKI; HIASA, YOICHI; GOH, YASUMASA; MIYAZAKI, TAKASHI; KOHARA, MICHINORI: "HBS-Large Hybrid Protein Vaccination Via Intranasal Route with Carboxyl Vinyl Polymer Rapidly Induced Strong Neutralizing Antibody and Anti-HBS IgA", HEPATOLOGY, vol. 70, no. S1, 1 January 2019 (2019-01-01), US , pages 605A, XP009553573, ISSN: 0270-9139
SANADA, TAKAHIRO; KAYESH, MOHAMMAD; HASEGAWA, HIDEKI; HIASA, YOICHI; GOH, YASUMASA; MIYAZAKI, TAKASHI; KOHARA, MICHINORI: "HBS-Large Hybrid Protein Vaccination Via Intranasal Route with Carboxyl Vinyl Polymer Rapidly Induced Strong Neutralizing Antibody and Anti-HBS IgA", HEPATOLOGY, vol. 70, no. S1, 1 January 2019 (2019-01-01), US , pages 605A, XP009553573, ISSN: 0270-9139
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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