Title:
HEPATITIS C VIRUS EPITOPE
Document Type and Number:
WIPO Patent Application WO/1998/016647
Kind Code:
A1
Abstract:
A peptide containing an amino acid sequence represented by X�1aa?-X�2aa?-Gln-X�3aa?-Ile-Gln-Leu (wherein X�1aa?, X�2aa? and X�3aa? represent each an arbitrary amino acid) and being capable of binding to a neutralizing antibody in the chimpanzee serum inhibiting the infection with hepatitis C virus (HCV); a DNA fragment having a base sequence encoding this peptide; an HCV-neutralizing antibody obtained by using the above-mentioned peptide as an immunogen; an anti-idiotype antibody against the above-mentioned antibody; a hepatitis C vaccine containing as the main ingredient the above-mentioned peptide, DNA fragment or anti-idiotype antibody; a remedy for hepatitis C containing as the main ingredient the above-mentioned HCV-neutralizing antibody; a method for detecting HCV and a method for detecting an antibody against HCV with the use of the above-mentioned HCV-neutralizing antibody or anti-idiotype antibody; and a method for eliciting the HCV-neutralizing antibody by using the above-mentioned peptide, DNA fragment or anti-idiotype antibody.
Inventors:
NISHIMURA SHINICHIRO (JP)
RIKIHISA TETSUJI (JP)
MAKIZUMI KEIICHI (JP)
NISHIHARA TSUKASA (JP)
NOZAKI CHIKATERU (JP)
MIZUNO KYOSUKE (JP)
RIKIHISA TETSUJI (JP)
MAKIZUMI KEIICHI (JP)
NISHIHARA TSUKASA (JP)
NOZAKI CHIKATERU (JP)
MIZUNO KYOSUKE (JP)
Application Number:
PCT/JP1997/003551
Publication Date:
April 23, 1998
Filing Date:
October 03, 1997
Export Citation:
Assignee:
CHEMO SERO THERAPEUT RES INST (JP)
NISHIMURA SHINICHIRO (JP)
RIKIHISA TETSUJI (JP)
MAKIZUMI KEIICHI (JP)
NISHIHARA TSUKASA (JP)
NOZAKI CHIKATERU (JP)
MIZUNO KYOSUKE (JP)
NISHIMURA SHINICHIRO (JP)
RIKIHISA TETSUJI (JP)
MAKIZUMI KEIICHI (JP)
NISHIHARA TSUKASA (JP)
NOZAKI CHIKATERU (JP)
MIZUNO KYOSUKE (JP)
International Classes:
A61K39/29; A61K39/395; C07K14/18; C07K16/10; C07K16/42; C12N15/09; C12N15/51; C12P21/08; G01N33/576; A61K39/00; (IPC1-7): C12N15/51; C07K14/18; C07K16/08; C07K16/42; A61K39/29; A61K39/42; G01N33/53
Domestic Patent References:
| WO1993006247A1 | 1993-04-01 | |||
| WO1993018054A2 | 1993-09-16 | |||
| WO1996040764A2 | 1996-12-19 | |||
| WO1994014974A1 | 1994-07-07 |
Foreign References:
| EP0726463A2 | 1996-08-14 |
Attorney, Agent or Firm:
Aoyama, Tamotsu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 540, JP)
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