HEPATITIS C VIRUS INFECTION INHIBITOR

WIPO Patent Application WO/2017/061599

A1

To develop and provide an HCV infection inhibitor that has a potent HCV infection inhibitory effect regardless of genotypes or mutations of HCV. Provided is an anti-occludin antibody that comprises a part of an amino acid sequence constituting the second extracellular domain of occludin and binds to a peptide containing as an epitope an amino acid sequence represented by SEQ ID NO:1.

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CHIBA HIDEKI (JP)
TOMIKAWA NAOKI (JP)
OHIRA HIROMASA (JP)
OKAI KEN (JP)

PCT/JP2016/079955

April 13, 2017

October 07, 2016

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UNIV FUKUSHIMA MEDICAL (JP)

C07K16/28; A61K39/29; A61K39/395; A61P31/14; C12N15/02; C12P21/08

WO2016139941A1

2016-09-09

JP2012504647A

2012-02-23

LIU, SHUFENG ET AL.: "The second extracellular loop dictates Occludin-mediated HCV entry", VIROLOGY, vol. 407, 2010, pages 160 - 170, XP027318252
MICHTA, MARIA L. ET AL.: "Species-Specific Regions of Occludin Required by Hepatitis C Virus for Cell Entry", J. VIROLOGY, vol. 84, no. 22, November 2010 (2010-11-01), pages 11696 - 11708, XP055376251
SOURISSEAU, MARION ET AL.: "Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies", PLOS PATHOGENS, vol. 9, no. 3, March 2013 (2013-03-01), pages 1 - 11, XP055376254

HIRAKI Yusuke et al. (JP)

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