Title:
HEPATITIS C VIRUS REPLICATION SYSTEM
Document Type and Number:
WIPO Patent Application WO2006038129
Kind Code:
A3
Abstract:
A cell including: (a) a hepatitis C virus genome, and/or nucleic acid encoding a hepatitis C virus genome; and (b) nucleic acid encoding one or both of hepatitis C virus proteins El and E2. The cells can be grown in culture in order to support HCV replication, and HCV virions can be purified from them.
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Inventors:
MEROLA MARCELLO (IT)
Application Number:
PCT/IB2005/003957
Publication Date:
June 22, 2006
Filing Date:
October 03, 2005
Export Citation:
Assignee:
CHIRON SRL (IT)
MEROLA MARCELLO (IT)
MEROLA MARCELLO (IT)
International Classes:
A61K38/00; C07K14/18; A61K39/29; C12N5/10
Domestic Patent References:
| WO2005080575A1 | 2005-09-01 | |||
| WO2005028652A1 | 2005-03-31 | |||
| WO2006022422A1 | 2006-03-02 |
Other References:
JEONG S-H ET AL: "65 Induction of HCV-specific immune responses by hepatitis C virus-like particles in non-human primates: implications for prevention and therapy of hepatitis C", HEPATOLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 38, 2003, pages 186, XP004623281, ISSN: 0270-9139
PIETSCHMANN THOMAS ET AL: "Persistent and transient replication of full-length hepatitis C virus genomes in cell culture", JOURNAL OF VIROLOGY, vol. 76, no. 8, April 2002 (2002-04-01), pages 4008 - 4021, XP002377301, ISSN: 0022-538X
DRUMMER HEIDI E ET AL: "Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteins.", FEBS LETTERS, vol. 546, no. 2-3, 10 July 2003 (2003-07-10), pages 385 - 390, XP004433679, ISSN: 0014-5793
HARADA TAKASHI ET AL: "E2-p7 region of the bovine viral diarrhea virus polyprotein: Processing and functional studies", JOURNAL OF VIROLOGY, vol. 74, no. 20, October 2000 (2000-10-01), pages 9498 - 9506, XP002377303, ISSN: 0022-538X
ABRAHAM J-D ET AL: "Comparative immunogenicity analysis of modified vaccinia Ankara vectors expressing native or modified forms of hepatitis C virus E1 and E2 glycoproteins", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 22, no. 29-30, 28 September 2004 (2004-09-28), pages 3917 - 3928, XP004567469, ISSN: 0264-410X
DE BEECK ANNE OP ET AL: "Characterization of functional hepatitis C virus envelope glycoproteins.", JOURNAL OF VIROLOGY, vol. 78, no. 6, March 2004 (2004-03-01), pages 2994 - 3002, XP002377304, ISSN: 0022-538X
PIETSCHMANN THOMAS ET AL: "Persistent and transient replication of full-length hepatitis C virus genomes in cell culture", JOURNAL OF VIROLOGY, vol. 76, no. 8, April 2002 (2002-04-01), pages 4008 - 4021, XP002377301, ISSN: 0022-538X
DRUMMER HEIDI E ET AL: "Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteins.", FEBS LETTERS, vol. 546, no. 2-3, 10 July 2003 (2003-07-10), pages 385 - 390, XP004433679, ISSN: 0014-5793
HARADA TAKASHI ET AL: "E2-p7 region of the bovine viral diarrhea virus polyprotein: Processing and functional studies", JOURNAL OF VIROLOGY, vol. 74, no. 20, October 2000 (2000-10-01), pages 9498 - 9506, XP002377303, ISSN: 0022-538X
ABRAHAM J-D ET AL: "Comparative immunogenicity analysis of modified vaccinia Ankara vectors expressing native or modified forms of hepatitis C virus E1 and E2 glycoproteins", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 22, no. 29-30, 28 September 2004 (2004-09-28), pages 3917 - 3928, XP004567469, ISSN: 0264-410X
DE BEECK ANNE OP ET AL: "Characterization of functional hepatitis C virus envelope glycoproteins.", JOURNAL OF VIROLOGY, vol. 78, no. 6, March 2004 (2004-03-01), pages 2994 - 3002, XP002377304, ISSN: 0022-538X
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