Title:
HETEROALKYL BIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2010/042652
Kind Code:
A3
Abstract:
Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
Inventors:
HUTCHINSON JOHN HOWARD (US)
SEIDERS THOMAS JON (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
SEIDERS THOMAS JON (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
Application Number:
PCT/US2009/059891
Publication Date:
July 29, 2010
Filing Date:
October 07, 2009
Export Citation:
Assignee:
AMIRA PHARMACEUTICALS INC (US)
HUTCHINSON JOHN HOWARD (US)
SEIDERS THOMAS JON (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
HUTCHINSON JOHN HOWARD (US)
SEIDERS THOMAS JON (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
International Classes:
C07C57/32; A61K31/41; A61K31/433; A61P11/00; A61P11/06; C07D285/125
Domestic Patent References:
| WO2003006011A1 | 2003-01-23 |
Other References:
SHRADER, WILLIAM D. ET AL.: "Factor VIla inhibitors: Gaining selectivity within the trypsin family", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 6, 2006, pages 1596 - 1600
PRIETO, MONICA ET AL.: "Racemization in Suzuki couplings: a quantitative study using 4-hydroxyphenylglycine and tyrosine derivatives as probe molecules", JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 3, 2007, pages 1047 - 1050
PRIETO, MONICA ET AL.: "Racemization in Suzuki couplings: a quantitative study using 4-hydroxyphenylglycine and tyrosine derivatives as probe molecules", JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 3, 2007, pages 1047 - 1050
Attorney, Agent or Firm:
HOSTETLER, Michael et al. (650 Page Mill RoadPalo Alto, CA, US)
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