Title:
HETEROAROMATIC COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/036285
Kind Code:
A1
Abstract:
A heteroaromatic compound and an application thereof. Specifically, provided is a compound as represented by formula I, or an optical isomer, raceme, solvate, hydrate, pharmaceutically-acceptable salt, or prodrug thereof. The compound has excellent preventive and therapeutic effects on tumors.
Inventors:
ZHANG JUNBO (CN)
ZHU SHUHAO (CN)
QI XIAOXIN (CN)
ZHU SHUHAO (CN)
QI XIAOXIN (CN)
Application Number:
PCT/CN2022/118064
Publication Date:
March 16, 2023
Filing Date:
September 09, 2022
Export Citation:
Assignee:
ORIMOS THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/4375; A61K31/4704; A61P35/00; C07D215/227; C07D401/10; C07D401/12
Domestic Patent References:
| WO2022074124A1 | 2022-04-14 | |||
| WO2021013735A1 | 2021-01-28 | |||
| WO2009053373A1 | 2009-04-30 |
Foreign References:
| CN107849040A | 2018-03-27 | |||
| US20120129868A1 | 2012-05-24 |
Other References:
JOHANNES JEFFREY W., BALAZS AMBER, BARRATT DEREK, BISTA MICHAL, CHUBA MATTHEW D., COSULICH SABINA, CRITCHLOW SUSAN E., DEGORCE SÉB: "Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 19, 14 October 2021 (2021-10-14), US , pages 14498 - 14512, XP093028792, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01012
Attorney, Agent or Firm:
PANCHINA IP LAW OFFICE (CN)
Download PDF: