Title:
HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/089918
Kind Code:
A1
Abstract:
A heteroaromatic pentacyclic compound of the general formula: [I] [wherein V is CH or N; W is S or O; each of R1 and R2 is H, etc.; X is -N(R4)-, -O-, -S-, -SO2-N(R5)-, -CO-N(R7)-, etc.; L is formula [II]; (Each of R20, R21, R22 and R25 is H, etc.; and E is an aryl or an aromatic heterocycle); R is -COOH, etc.; B is an aryl, etc.; R3 is H, etc.; Y is -C(R13)(R14)-N(R12)-, -C(R13)(R14)-O-, -N(R11)-, -O-, etc.; A is an alkylene; Z is an aryl, etc.; etc.]. This compound or its prodrug or a pharmaceutically acceptable salt thereof has a protein tyrosine phosphatase 1B inhibiting activity and is useful as a curative medicine for diabetes mellitus, diabetes mellitus complications, hyperlipemia or obesity.
Inventors:
Ikemoto, Tomoyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Tanaka, Masahiro c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Yuno, Takeo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakamoto, Johei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakanishi, Hiroyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakagawa, Yuichi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Ohta, Takeshi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakata, Shohei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Morinaga, Hisayo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Tanaka, Masahiro c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Yuno, Takeo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakamoto, Johei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakanishi, Hiroyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakagawa, Yuichi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Ohta, Takeshi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakata, Shohei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Morinaga, Hisayo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Application Number:
PCT/JP2004/005119
Publication Date:
October 21, 2004
Filing Date:
April 09, 2004
Export Citation:
Assignee:
JAPAN TOBACCO INC. (2-1 Toranomon 2-chome, Minato-ku, Tokyo, 105-8422, JP)
Ikemoto, Tomoyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Tanaka, Masahiro c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Yuno, Takeo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakamoto, Johei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakanishi, Hiroyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakagawa, Yuichi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Ohta, Takeshi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakata, Shohei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Morinaga, Hisayo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Ikemoto, Tomoyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Tanaka, Masahiro c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Yuno, Takeo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakamoto, Johei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakanishi, Hiroyuki c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Nakagawa, Yuichi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Ohta, Takeshi c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Sakata, Shohei c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
Morinaga, Hisayo c/o Central Pharmaceutical Research Institute of Japan Tobacco Inc. (1-1 Murasaki-ch, Takatsuki-shi Osaka, 569-1125, JP)
International Classes:
A61K31/381; A61K31/405; A61K31/4155; A61K31/4184; A61K31/421; A61K31/423; A61K31/427; A61K31/428; A61K31/4439; A61K31/4725; A61K31/497; A61K31/538; A61P3/04; A61P3/06; A61P3/10; A61P43/00; C07D263/32; C07D277/28; C07D333/20; C07D409/12; C07D413/12; C07D417/04; C07D417/12; C07D417/14; (IPC1-7): C07D263/32; C07D417/14; C07D333/20; C07D413/12; C07D417/06; C07D409/12; C07D333/38; C07D333/16; C07D333/18; C07D277/22; C07D277/28; C07D417/12; A61K31/421; A61K31/4439; A61K31/4725; A61K31/538; A61K31/497; A61K31/4184; A61K31/427; A61K31/428; A61K31/381; A61K31/405; A61K31/4155; A61K31/423; A61K45/00; A61P43/00; A61P3/10; A61P3/06; A61P3/04
Attorney, Agent or Firm:
Takashima, Hajime (Meji Yasuda Seimei Osaka Midosuji Bldg. 1-1, Fushimimachi 4-chome,, Chuo-ku, Osaka-sh, Osaka, 541-0044, JP)
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