Title:
HETEROARYL AMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/221433
Kind Code:
A1
Abstract:
Provided is a novel compound, and a pharmaceutically acceptable salt thereof, that has an action of reducing blood sugar and the like, and that is useful as a therapeutic and/or preventive medicine for diseases such as diabetes. Provided is a heteroaryl amine derivative represented by formula (I), or a salt thereof, or a crystal thereof, the formula having various substituents (here, the meanings of A, B, C, R1, R2, R3, R4, R5, and R6 in formula (I) are as defined in the specification).
Inventors:
YAMAGUCHI MITSUHIRO (JP)
TSUJI TAKASHI (JP)
BABA TAKAYUKI (JP)
KUROYANAGI JUNICHI (JP)
INUI MASAHARU (JP)
KOMORIYA SATOSHI (JP)
MATSUFUJI TETSUYOSHI (JP)
FURUZONO SHINJI (JP)
TSUJI TAKASHI (JP)
BABA TAKAYUKI (JP)
KUROYANAGI JUNICHI (JP)
INUI MASAHARU (JP)
KOMORIYA SATOSHI (JP)
MATSUFUJI TETSUYOSHI (JP)
FURUZONO SHINJI (JP)
Application Number:
PCT/JP2018/020268
Publication Date:
December 06, 2018
Filing Date:
May 28, 2018
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07D237/26; A61K31/502; A61K31/5025; A61K31/517; A61K31/519; A61K31/53; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P7/10; A61P9/10; A61P9/12; A61P13/12; C07D239/80; C07D277/24; C07D401/12; C07D403/12; C07D405/04; C07D417/12; C07D487/04; C07D491/048; C07D495/04
Domestic Patent References:
| WO2014074761A2 | 2014-05-15 | |||
| WO2006066937A2 | 2006-06-29 |
Other References:
OHNO, A. ET AL.: "Physical Properties of Atropisomeric 5-Deazaflavin Derivatives", TETRAHEDRON, vol. 53, no. 13, 1997, pages 4601 - 4610, XP004105521
OHNO, A. ET AL.: "Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring: Syntheses, Physical Properties, and Stereochemistry in the Reactions with NAD(P) H Analogs", J. ORG. CHEM., vol. 61, no. 26, 1996, pages 9344 - 9355, XP055570352
KAWAMOTO, T. ET AL.: "Synthesis and Reaction of Novel 5-Deazaflavins with Axial Chirality at Pyrimidine Ring Moiety", TETRAHEDRON LETTERS, vol. 33, no. 22, 1992, pages 3169 - 3172, XP001105117
ZHANG, Y. ET AL.: "De novo design of N-(pyridin-4- ylmethyl)aniline derivatives as KDR inhibitors: 3D- QSAR, molecular fragment replacement, protein- ligand interaction fingerprint, and ADMET prediction", MOL DIVERS, vol. 16, 2012, pages 787 - 802, XP035144528
DUNCTON, M. A. J. ET AL.: "Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, 2009, pages 731 - 740, XP025893448
DUNCTON, M. A. J. ET AL.: "Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 1579 - 1581, XP028755044
MEDDA, F. ET AL.: "Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PEG2 production in cells", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 528 - 531, XP055570368
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DATABASE REGISTRY [O] 21 April 2016 (2016-04-21), Database accession no. 1894510-00-9
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DATABASE REGISTRY [O] 21 April 2016 (2016-04-21), Database accession no. 1894291-66-7
DATABASE REGISTRY [O] 18 April 2016 (2016-04-18), Database accession no. 1892460-01-3
DATABASE REGISTRY [O] 18 April 2016 (2016-04-18), Database accession no. 1892399-34-6
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890992-40-1
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890704-72-9
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890563-07-1
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890431-38-5
DATABASE REGISTRY [O] 6 December 2011 (2011-12-06), Database accession no. 1349446-54-3
DATABASE REGISTRY [O] 6 December 2011 (2011-12-06), Database accession no. 1349425-89-3
DATABASE REGISTRY [O] 8 September 2011 (2011-09-08), Database accession no. 1330184-80-9
DATABASE REGISTRY [O] 8 September 2011 (2011-09-08), Database accession no. 1330165-15-5
DATABASE REGISTRY [O] 7 September 2011 (2011-09-07), Database accession no. 1329648-27-2
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-75-2
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-73-0
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-72-9
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-71-8
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-61-6
PARK, H. ET AL.: "Discovery of novel alpha-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 284 - 292, XP022485949
OHNO, A. ET AL.: "Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring: Syntheses, Physical Properties, and Stereochemistry in the Reactions with NAD(P) H Analogs", J. ORG. CHEM., vol. 61, no. 26, 1996, pages 9344 - 9355, XP055570352
KAWAMOTO, T. ET AL.: "Synthesis and Reaction of Novel 5-Deazaflavins with Axial Chirality at Pyrimidine Ring Moiety", TETRAHEDRON LETTERS, vol. 33, no. 22, 1992, pages 3169 - 3172, XP001105117
ZHANG, Y. ET AL.: "De novo design of N-(pyridin-4- ylmethyl)aniline derivatives as KDR inhibitors: 3D- QSAR, molecular fragment replacement, protein- ligand interaction fingerprint, and ADMET prediction", MOL DIVERS, vol. 16, 2012, pages 787 - 802, XP035144528
DUNCTON, M. A. J. ET AL.: "Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, 2009, pages 731 - 740, XP025893448
DUNCTON, M. A. J. ET AL.: "Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 1579 - 1581, XP028755044
MEDDA, F. ET AL.: "Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PEG2 production in cells", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 528 - 531, XP055570368
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-76-3
DATABASE REGISTRY [O] 24 April 2016 (2016-04-24), Database accession no. 1896203-81-8
DATABASE REGISTRY [O] 22 April 2016 (2016-04-22), Database accession no. 1895602-81-9
DATABASE REGISTRY [O] 22 April 2016 (2016-04-22), Database accession no. 1895240-15-9
DATABASE REGISTRY [O] 21 April 2016 (2016-04-21), Database accession no. 1894775-33-7
DATABASE REGISTRY [O] 21 April 2016 (2016-04-21), Database accession no. 1894510-00-9
DATABASE REGISTRY [O] 21 April 2016 (2016-04-21), Database accession no. 1894291-88-3
DATABASE REGISTRY [O] 21 April 2016 (2016-04-21), Database accession no. 1894291-66-7
DATABASE REGISTRY [O] 18 April 2016 (2016-04-18), Database accession no. 1892460-01-3
DATABASE REGISTRY [O] 18 April 2016 (2016-04-18), Database accession no. 1892399-34-6
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890992-40-1
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890704-72-9
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890563-07-1
DATABASE REGISTRY [O] 15 April 2016 (2016-04-15), Database accession no. 1890431-38-5
DATABASE REGISTRY [O] 6 December 2011 (2011-12-06), Database accession no. 1349446-54-3
DATABASE REGISTRY [O] 6 December 2011 (2011-12-06), Database accession no. 1349425-89-3
DATABASE REGISTRY [O] 8 September 2011 (2011-09-08), Database accession no. 1330184-80-9
DATABASE REGISTRY [O] 8 September 2011 (2011-09-08), Database accession no. 1330165-15-5
DATABASE REGISTRY [O] 7 September 2011 (2011-09-07), Database accession no. 1329648-27-2
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-75-2
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-73-0
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-72-9
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-71-8
DATABASE REGISTRY [O] 25 February 2005 (2005-02-25), Database accession no. 837395-61-6
PARK, H. ET AL.: "Discovery of novel alpha-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 284 - 292, XP022485949
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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