Title:
HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/061247
Kind Code:
A3
Abstract:
The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Inventors:
QIU HUI (US)
CALDWELL RICHARD D (US)
NEAGU CONSTANTIN (US)
MOCHALKIN IGOR (US)
LIU-BUJALSKI LESLEY (US)
JONES REINALDO (US)
TATE DEVON (US)
JOHNSON THERESA L (US)
GARDBERG ANNA (US)
CALDWELL RICHARD D (US)
NEAGU CONSTANTIN (US)
MOCHALKIN IGOR (US)
LIU-BUJALSKI LESLEY (US)
JONES REINALDO (US)
TATE DEVON (US)
JOHNSON THERESA L (US)
GARDBERG ANNA (US)
Application Number:
PCT/US2014/061455
Publication Date:
July 23, 2015
Filing Date:
October 21, 2014
Export Citation:
Assignee:
MERCK PATENT GMBH (DE)
QIU HUI (US)
CALDWELL RICHARD D (US)
NEAGU CONSTANTIN (US)
MOCHALKIN IGOR (US)
LIU-BUJALSKI LESLEY (US)
JONES REINALDO (US)
TATE DEVON (US)
JOHNSON THERESA L (US)
GARDBERG ANNA (US)
QIU HUI (US)
CALDWELL RICHARD D (US)
NEAGU CONSTANTIN (US)
MOCHALKIN IGOR (US)
LIU-BUJALSKI LESLEY (US)
JONES REINALDO (US)
TATE DEVON (US)
JOHNSON THERESA L (US)
GARDBERG ANNA (US)
International Classes:
A61K31/4439; C07D403/12; A61K31/506; C07D213/81; C07D239/48; C07D401/04; C07D401/12; C07D403/04; C07D407/04; C07D409/04; C07D413/04; C07D413/06; C07D487/04
Domestic Patent References:
WO2013030665A1 | 2013-03-07 | |||
WO2008009458A1 | 2008-01-24 | |||
WO2010144647A1 | 2010-12-16 | |||
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Foreign References:
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Other References:
CHRISTIAN DELVARE ET AL: "Efficient Three-Step One-Pot Synthesis of a Novel 2,3,5-Substituted Pyrazine Library", ACS COMBINATORIAL SCIENCE, vol. 13, no. 5, 12 September 2011 (2011-09-12), pages 449 - 452, XP055157727, ISSN: 2156-8952, DOI: 10.1021/co200062n
GARY PHILLIPS ET AL: "Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 44, no. 10, 20 May 1999 (1999-05-20), pages 1349 - 1355, XP002595442, ISSN: 0022-2623, [retrieved on 19990424], DOI: 10.1021/JM980667K
YONGJUN MAO ET AL: "Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 11, 1 June 2013 (2013-06-01), pages 3090 - 3104, XP055183165, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.03.053
GARY PHILLIPS ET AL: "Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 44, no. 10, 20 May 1999 (1999-05-20), pages 1349 - 1355, XP002595442, ISSN: 0022-2623, [retrieved on 19990424], DOI: 10.1021/JM980667K
YONGJUN MAO ET AL: "Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 11, 1 June 2013 (2013-06-01), pages 3090 - 3104, XP055183165, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.03.053
Attorney, Agent or Firm:
KIM, Dwight D. (One Technology PlaceRockland, Massachusetts, US)
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