Title:
HETEROARYL-SUBSTITUTED PYRAZOLE COMPOUND AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/194207
Kind Code:
A1
Abstract:
Disclosed are: a heteroaryl-substituted pyrazole compound or a pharmaceutically acceptable salt thereof having SGLT1 inhibitory activity and medicinal usefulness; a medicinal composition comprising same; and medicinal uses of the compound, salt, and composition. Specifically, a compound represented by formula [X] (in the formula, R1 is hydrogen or halogen, R2 is C1-6 alkyl or halo-C1-6-alkyl, RingHet is a substituted pyridyl or a substitutable pyrazinyl, pyrimidinyl or pyridazinyl) or a pharmaceutically acceptable salt thereof, a medicinal composition comprising same, and medicinal uses of the compound, salt, and composition are provided.
Inventors:
MIURA TOMOYA (JP)
HIRASHIMA SHINTARO (JP)
MANABE TOMOYUKI (JP)
IIDA TETSUYA (JP)
SAKURAI KENTARO (JP)
HIRASHIMA SHINTARO (JP)
MANABE TOMOYUKI (JP)
IIDA TETSUYA (JP)
SAKURAI KENTARO (JP)
Application Number:
PCT/JP2019/014721
Publication Date:
October 10, 2019
Filing Date:
April 03, 2019
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D403/14; A61K31/4439; A61K31/506; A61P3/10; A61P43/00; C07D401/14
Domestic Patent References:
| WO2013031922A1 | 2013-03-07 | |||
| WO2013031922A1 | 2013-03-07 |
Foreign References:
| JP2008007405A | 2008-01-17 | |||
| JP2009544572A | 2009-12-17 |
Other References:
AM J PHYSIOL GASTROINTEST LIVER PHYSIOL, vol. 282, no. 2, 2002, pages G241 - 8
NATURE, vol. 350, no. 6316, 1991, pages 354 - 6
J MOL CELL CARDIOL, vol. 49, no. 4, 2010, pages 683 - 92
CARDIOVASC RES, vol. 84, no. 1, 2009, pages 111 - 8
CANCER CELL, vol. 13, 2008, pages 385 - 93
PHARMACOL THER, vol. 121, 2009, pages 29 - 40
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 19
STAHL ET AL.: "Handbook of Pharmaceutical Salt: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
"GenBank", Database accession no. NM_000343
See also references of EP 3778593A4
NATURE, vol. 350, no. 6316, 1991, pages 354 - 6
J MOL CELL CARDIOL, vol. 49, no. 4, 2010, pages 683 - 92
CARDIOVASC RES, vol. 84, no. 1, 2009, pages 111 - 8
CANCER CELL, vol. 13, 2008, pages 385 - 93
PHARMACOL THER, vol. 121, 2009, pages 29 - 40
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 19
STAHL ET AL.: "Handbook of Pharmaceutical Salt: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
"GenBank", Database accession no. NM_000343
See also references of EP 3778593A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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