HETEROARYLCARBAMOYLBENZENE DERIVATIVE

Title:

HETEROARYLCARBAMOYLBENZENE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2004/076420

Kind Code:

A1

Abstract:

A compound represented by the following formula (I): (I) [wherein X¹ represents oxygen, etc.; X² represents oxygen, etc.; R¹ represents an alkylsulfonyl or another group on the ring A; R² represents, e.g., C_3-7 cyclic alkyl optionally substituted by halogeno, etc.; R³ represents a substituent on the ring B, e.g., lower alkyl; the formula (II) [Chemical formula 1] (II) represents 6- to 10-membered aryl, etc.; and the formula (III) [Chemical formula 1] (III) represents a mono- or bicyclic heteroaryl which optionally has a substituent represented by the R³ in the ring B and in which the carbon atom bonded to the nitrogen atom of the amide group in the formula (I) forms C=N in cooperation with the nitrogen atom of the ring] or a pharmaceutically acceptable salt of the compound. The compound and salt function to activate glucokinase and are useful as a therapeutic agent for diabetes.

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Inventors:

IINO TOMOHARU (JP)
HASHIMOTO NORIAKI (JP)
NAKASHIMA HIROSHI (JP)
TAKAHASHI KEIJI (JP)
NISHIMURA TERUYUKI (JP)
EIKI JUN-ICHI (JP)

Application Number:

PCT/JP2004/002284

Publication Date:

September 10, 2004

Filing Date:

February 26, 2004

Export Citation:

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Assignee:

BANYU PHARMA CO LTD (JP)
IINO TOMOHARU (JP)
HASHIMOTO NORIAKI (JP)
NAKASHIMA HIROSHI (JP)
TAKAHASHI KEIJI (JP)
NISHIMURA TERUYUKI (JP)
EIKI JUN-ICHI (JP)

International Classes:

A61P3/04; A61P3/10; A61P43/00; C07D213/75; C07D231/40; C07D237/20; C07D239/42; C07D241/20; C07D249/04; C07D261/14; C07D271/07; C07D275/03; C07D277/18; C07D277/46; C07D277/60; C07D277/82; C07D285/08; C07D285/10; C07D285/135; C07D401/12; C07D405/14; C07D413/12; C07D417/12; C07D417/14; C07D513/04; C07D271/06; C07D275/02; C07D285/12; (IPC1-7): C07D213/75; C07D213/80; C07D231/40; C07D239/42; C07D241/20; C07D237/20; C07D277/46; C07D285/12; C07D285/08; C07D417/12; C07D401/12; C07D261/14; C07D271/07; C07D249/04; C07D513/04; A61K31/415; A61K31/42; A61K31/426; A61K31/427; A61K31/433; A61K31/437; A61K31/44; A61K31/4402; A61K31/4439; A61K31/444; A61K31/454; A61K31/4965; A61K31/505; A61K31/4245; A61K31/4192; A61K31/429; A61K31/455; A61K31/495; A61P3/04; A61P3/10; A61P43/00

Domestic Patent References:

WO2003080585A1	2003-10-02
WO2003000267A1	2003-01-03

Other References: