Title:
HETEROCYCIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/030743
Kind Code:
A1
Abstract:
Provided is a compound which has an excellent FLAP inhibitory activity and is useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, or a salt of the compound. The present invention relates to a compound represented by formula (I) or a salt thereof.
(In the formula, the symbols are as defined in the description.)
Inventors:
OGINO MASAKI (JP)
IKEDA ZENICHI (JP)
FUJIMOTO JUN (JP)
OHBA YUSUKE (JP)
ISHII NAOKI (JP)
FUJIMOTO TAKUYA (JP)
ODA TSUNEO (JP)
TAYA NAOHIRO (JP)
YAMASHITA TOSHIRO (JP)
MATSUNAGA NOBUYUKI (JP)
IKEDA ZENICHI (JP)
FUJIMOTO JUN (JP)
OHBA YUSUKE (JP)
ISHII NAOKI (JP)
FUJIMOTO TAKUYA (JP)
ODA TSUNEO (JP)
TAYA NAOHIRO (JP)
YAMASHITA TOSHIRO (JP)
MATSUNAGA NOBUYUKI (JP)
Application Number:
PCT/JP2013/072562
Publication Date:
February 27, 2014
Filing Date:
August 23, 2013
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
International Classes:
C07D239/80; A61K31/517; A61K31/519; A61K31/5377; A61P9/10; A61P43/00; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/12; C07D413/04; C07D417/12; C07D471/04; C07D487/04; C07D513/04; C07D519/00
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Other References:
COLOTTA, V. ET AL.: "Synthesis and biological evaluation of a series of quinazoline-2- carboxylic acids and quinazoline-2,4-diones as glycine-NMDA antagonists.", A PHARMACOPHORE MODEL -BASED APPROACH, ARCHIV DER PHARMAZIE, vol. 330, no. 5, 1997, pages 129 - 134, XP055190615
See also references of EP 2889291A4
HELGADOTTIR ET AL., NATURE GENETICS, vol. 36, 2004, pages 233 - 239
"Jikken Kagaku Kouza", vol. 14, pages: 251 - 253
"Jikken Kagaku Kouza", vol. 19, pages: 273 - 274
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE, INC.
"IYAKUHIN no KAIHATSU", vol. 7, 1990, HIROKAWA SHOTEN, article "Design of Molecules", pages: 163 - 198
See also references of EP 2889291A4
HELGADOTTIR ET AL., NATURE GENETICS, vol. 36, 2004, pages 233 - 239
"Jikken Kagaku Kouza", vol. 14, pages: 251 - 253
"Jikken Kagaku Kouza", vol. 19, pages: 273 - 274
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE, INC.
"IYAKUHIN no KAIHATSU", vol. 7, 1990, HIROKAWA SHOTEN, article "Design of Molecules", pages: 163 - 198
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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