Title:
HETEROCYCLIC AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/052065
Kind Code:
A1
Abstract:
Provided is a heterocyclic compound that can have a PRS inhibitory effect and is expected to be of use as a prophylaxis or a therapeutic agent for PRS-related diseases, including cancer. A compound or a salt thereof, said compound being expressed by formula (I) (wherein the group expressed by (3) indicates a group expressed by formula (II) or formula (III), and the other symbols are as indicated in the specification).
Inventors:
HIRAYAMA TAKAHARU (JP)
HIRATA YASUHIRO (JP)
TOMINARI YUSUKE (JP)
IWAMURA NAOKI (JP)
SASAKI YUSUKE (JP)
ASANO MORITERU (JP)
TAKAGI TERUFUMI (JP)
OKANIWA MASANORI (US)
YOSHIDA MASATO (JP)
ICHIKAWA TAKASHI (JP)
IMAMURA SHINICHI (JP)
HIRATA YASUHIRO (JP)
TOMINARI YUSUKE (JP)
IWAMURA NAOKI (JP)
SASAKI YUSUKE (JP)
ASANO MORITERU (JP)
TAKAGI TERUFUMI (JP)
OKANIWA MASANORI (US)
YOSHIDA MASATO (JP)
ICHIKAWA TAKASHI (JP)
IMAMURA SHINICHI (JP)
Application Number:
PCT/JP2017/033213
Publication Date:
March 22, 2018
Filing Date:
September 14, 2017
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D401/04; A61K31/437; A61K31/4439; A61K31/444; A61K31/501; A61K31/506; A61K31/52; A61K31/5377; A61P35/00; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D473/00; C07D473/28; C07D473/32; C07D473/40; C07D519/00; C12N9/99
Domestic Patent References:
| WO2009006389A2 | 2009-01-08 | |||
| WO2009006404A2 | 2009-01-08 | |||
| WO2008063669A1 | 2008-05-29 | |||
| WO2015016206A1 | 2015-02-05 |
Foreign References:
| JP2015506363A | 2015-03-02 | |||
| JP2011530596A | 2011-12-22 | |||
| JP2007502861A | 2007-02-15 | |||
| JP2016180748A | 2016-10-13 |
Other References:
JAIN V ET AL., STRUCTURE, vol. 23, 5 May 2015 (2015-05-05), pages 819 - 829
KELLER TL ET AL., NAT CHEM BIOL., vol. 8, no. 3, 12 February 2012 (2012-02-12), pages 311 - 7
LAMORA A ET AL., ONCOTARGET., vol. 6, no. 16, 10 June 2015 (2015-06-10), pages 14413 - 27
CHEN GQ ET AL., ONCOTARGET., vol. 6, no. 27, 15 September 2015 (2015-09-15), pages 24148 - 62
KIM S ET AL., NAT REV CANCER, vol. 11, no. 10, 23 September 2011 (2011-09-23), pages 708 - 18
"Jikken Kagaku Kouza", vol. 13-19
"Shinjikken Kagaku Kouza (Courses in Experimental Chemistry", vol. 14-15
L. F. TIETZE; TH. EICHER: "Fine Organic Chemistry rev.", NANKODO
HIDEO TOGO: "Their Mechanism and Essence", KODANSHA, article "Organic Name Reactions"
"ORGANIC SYNTHESES Collective", vol. I - VII, JOHN WILEY & SONS INC
JIE JACK LI: "Modern Organic Synthesis in the Laboratory", OXFORD UNIVERSITY, article "A Collection of Standard Experimental Procedures"
"Comprehensive Heterocyclic Chemistry III", vol. 1-14, ELSEVIER JAPAN KK
"Strategic Applications of Named Reactions in Organic Synthesis", KAGAKUDOJIN
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P. J. KOCIENSKI: "Protecting Groups", 2004, THIEME
J. F. HARTWIG; S. SHEKHAR; Q. SHEN; F. BARRIOS-LANDEROS: "The Chemistry of Anilines, Z. Rappoport", 2007, WILEY-INTERSICENCE
L. JIANG; S. L. BUCHWALD: "Metal-Catalyzed Cross-Coupling Reactions", 2004, WILEY-VCH
J. F. HARTWIG: "Handbook of Organopalladium Chemistry for Organic Synthesis", 2002, WILEY
J. F. HARTWIG: "Modern Amination Methods", 2000, WILEY-VCH
"Fifth Series of Experimental Chemistry", vol. 13-19
"Experimental Chemistry", vol. 14-15
L.F. TIETZE; TH. EICHER: "Fine Organic Chemistry", NANKODO
HIDEO TOGO: "Organic Name Reaction", KODANSHA
"ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONSINC
JIE JACK LI: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", OXFORD UNIVERSITY
"Comprehensive Heterocyclic Chemistry III", vol. 1-14, ELSEVIER
"Design of Molecules", vol. 7, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3514149A4
KELLER TL ET AL., NAT CHEM BIOL., vol. 8, no. 3, 12 February 2012 (2012-02-12), pages 311 - 7
LAMORA A ET AL., ONCOTARGET., vol. 6, no. 16, 10 June 2015 (2015-06-10), pages 14413 - 27
CHEN GQ ET AL., ONCOTARGET., vol. 6, no. 27, 15 September 2015 (2015-09-15), pages 24148 - 62
KIM S ET AL., NAT REV CANCER, vol. 11, no. 10, 23 September 2011 (2011-09-23), pages 708 - 18
"Jikken Kagaku Kouza", vol. 13-19
"Shinjikken Kagaku Kouza (Courses in Experimental Chemistry", vol. 14-15
L. F. TIETZE; TH. EICHER: "Fine Organic Chemistry rev.", NANKODO
HIDEO TOGO: "Their Mechanism and Essence", KODANSHA, article "Organic Name Reactions"
"ORGANIC SYNTHESES Collective", vol. I - VII, JOHN WILEY & SONS INC
JIE JACK LI: "Modern Organic Synthesis in the Laboratory", OXFORD UNIVERSITY, article "A Collection of Standard Experimental Procedures"
"Comprehensive Heterocyclic Chemistry III", vol. 1-14, ELSEVIER JAPAN KK
"Strategic Applications of Named Reactions in Organic Synthesis", KAGAKUDOJIN
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P. J. KOCIENSKI: "Protecting Groups", 2004, THIEME
J. F. HARTWIG; S. SHEKHAR; Q. SHEN; F. BARRIOS-LANDEROS: "The Chemistry of Anilines, Z. Rappoport", 2007, WILEY-INTERSICENCE
L. JIANG; S. L. BUCHWALD: "Metal-Catalyzed Cross-Coupling Reactions", 2004, WILEY-VCH
J. F. HARTWIG: "Handbook of Organopalladium Chemistry for Organic Synthesis", 2002, WILEY
J. F. HARTWIG: "Modern Amination Methods", 2000, WILEY-VCH
"Fifth Series of Experimental Chemistry", vol. 13-19
"Experimental Chemistry", vol. 14-15
L.F. TIETZE; TH. EICHER: "Fine Organic Chemistry", NANKODO
HIDEO TOGO: "Organic Name Reaction", KODANSHA
"ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONSINC
JIE JACK LI: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", OXFORD UNIVERSITY
"Comprehensive Heterocyclic Chemistry III", vol. 1-14, ELSEVIER
"Design of Molecules", vol. 7, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3514149A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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