HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME

WIPO Patent Application WO/1997/002244

A1

Heterocyclic carboxylic acid derivatives represented by general formula (I) or physiologically acceptable salts thereof: wherein A is a heteroaryl group which has at least one nitrogen atom and may be substituted, or the like; B is heteroarylene, -CONH-, -CR6=CR7- (R6 and R7 being each H, lower alkyl or the like) or the like; D is arylene, heteroarylene or the like; n1 is 0 or 1; and M is hydroxyl, lower alkoxy or the like, which are novel retinoid-related compounds substituting for retinoic acid and useful as a preventive or remedy for various diseases.

WO/1984/002907	NEW ALKYL DIAMINE DERIVATIVES
JPS5649383	BETA-LACTAM COMPOUND
JP2007522200	Therapeutic combination of atypical antipsychotics and corticotropin-releasing factor antagonists

KIKUCHI KOUICHI (JP)
TAGAMI KATSUYA (JP)
YOSHIMURA HIROYUKI (JP)
HIBI SHIGEKI (JP)
NAGAI MITSUO (JP)
ABE SHINYA (JP)
OKITA MAKOTO (JP)
HIDA TAKAYUKI (JP)
HIGASHI SEIKO (JP)
TOKUHARA NAOKI (JP)
KOBAYASHI SEIICHI (JP)

PCT/JP1996/001782

January 23, 1997

June 27, 1996

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EISAI CO LTD (JP)
KIKUCHI KOUICHI (JP)
TAGAMI KATSUYA (JP)
YOSHIMURA HIROYUKI (JP)
HIBI SHIGEKI (JP)
NAGAI MITSUO (JP)
ABE SHINYA (JP)
OKITA MAKOTO (JP)
HIDA TAKAYUKI (JP)
HIGASHI SEIKO (JP)
TOKUHARA NAOKI (JP)
KOBAYASHI SEIICHI (JP)

A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/47; A61K31/495; A61K31/53; A61K31/535; A61P1/16; A61P11/00; A61P17/00; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D209/14; C07D253/06; C07D213/82; C07D215/22; C07D231/12; C07D233/66; C07D241/24; C07D241/38; C07D241/44; C07D241/46; C07D249/10; C07D401/04; C07D401/14; C07D403/04; C07D405/04; C07D405/06; C07D405/14; C07D407/04; C07D409/04; C07D413/04; C07D417/04; C07D471/04; C07D495/04; C10J3/00; (IPC1-7): C07D209/08; C07D213/80; C07D213/82; C07D231/12; C07D231/14; C07D241/42; C07D241/44; C07D253/06; C07D401/04; C07D401/14; C07D403/04; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D417/04; A61K31/40; A61K31/415; A61K31/44; A61K31/47; A61K31/495; A61K31/53; A61K31/535; A61K31/55

JPS63119425A	1988-05-24
JPS6354369A	1988-03-08
JPS62256831A	1987-11-09
JPS6058981A	1985-04-05
JPS59139379A	1984-08-10
JPS58219162A	1983-12-20
JPS59157044A	1984-09-06

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CHEMICAL ABSTRACTS, 88 (23), (1978), p. 513, Abstract No. 169217d, SZUCS LADISLAV et al., "Derivatives of .alpha.- and .beta.- Unsaturated Ketones Derived from Acetylpyridine. VIII. Spectral Properties of Some Pyridine Analogs of 1,3,5-Triphenyl-2-Pyrazoline"; & ACTA FAC. PHARM. UNIV. COMENIANAE, 30, (1977), p.
CHEMICAL ABSTRACTS, 74 (21), (1971), p. 125, Abstract No. 108600n, IYER, K.S.N. et al., "p-Aminosalicylic Acid Derivatives as Possible Tuberculostats"; & INDIAN J. CHEM., 8(11), (1970), p. 964-8.
HETEROCYCLES, 35(2), (1993), p. 975-95, HARRY H. WASSERMAN et al., "Synthesis and Characterization of Pyrrolinonecarboxylates Formed by Reaction of Vivinal Tricarbonyl Derivatives with Aldehyde Schiff Bases".
J. MED. CHEM., 11(2), (1968), p. 295-300, G.J. ATWELL et al., "Potential Antitumor Agents".
J. ORG. CHEM., 60(25), (1995), p. 8231-5, HARRY H. WASSERMAN et al., "Selective Oxidation of Phosphorus Ylides by Dimethyldioxirane. Application to the Formation of Vicinal Tricarbonyls".

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