Title:
HETEROCYCLIC COMPOUND ACTING AS ASK INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/015559
Kind Code:
A1
Abstract:
The present invention belongs to the field of medical chemistry, and relates to a class of heterocyclic compounds acting as ASK inhibitors and the use thereof. Specifically, provided are compounds as shown in formula A or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, methods for preparing same, pharmaceutical compositions containing these compounds and the use of these compounds or compositions in treating and/or preventing diseases associated with apoptosis signal-regulating kinase 1. The compounds of the present invention have an excellent apoptosis signal-regulating kinase 1 inhibitory activity, and show a great deal of promise in becoming therapeutic agents for diseases associated with apoptosis signal-regulating kinase 1.
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Inventors:
WANG YONG (CN)
ZHAO LIWEN (CN)
GE CHONGXUN (CN)
HUANG YIQIANG (CN)
CAO CHEN (CN)
LI QINGQING (CN)
JIANG HONG (CN)
HAN WEI (CN)
ZHANG ZHUOWEI (CN)
ZHANG YANAN (CN)
ZHAO LIWEN (CN)
GE CHONGXUN (CN)
HUANG YIQIANG (CN)
CAO CHEN (CN)
LI QINGQING (CN)
JIANG HONG (CN)
HAN WEI (CN)
ZHANG ZHUOWEI (CN)
ZHANG YANAN (CN)
Application Number:
PCT/CN2018/095897
Publication Date:
January 24, 2019
Filing Date:
July 17, 2018
Export Citation:
Assignee:
NANJING SANHOME PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/427; A61K31/4439; A61K31/444; A61K31/4725; A61P9/00; A61P25/28; A61P29/00; C07D417/14; C07D471/04; C07D498/08
Domestic Patent References:
| WO2016106384A1 | 2016-06-30 |
Foreign References:
| CN102482257A | 2012-05-30 | |||
| CN104080771A | 2014-10-01 |
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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