Title:
HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2020/216378
Kind Code:
A1
Abstract:
A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof, an application thereof, and a composition containing same. The compound is novel in structure and has good STAT5 inhibitory activity.
Inventors:
FU XIN-YUAN (CN)
LU CENBIN (CN)
LIU XINYU (CN)
LUFEI CHENGCHEN (CN)
ZHOU YI (CN)
LU CENBIN (CN)
LIU XINYU (CN)
LUFEI CHENGCHEN (CN)
ZHOU YI (CN)
Application Number:
PCT/CN2020/087008
Publication Date:
October 29, 2020
Filing Date:
April 26, 2020
Export Citation:
Assignee:
GENEROS BIOPHARMA LTD (CN)
International Classes:
C07D403/02; A61K31/445; A61K31/454; A61P19/02; A61P29/00; A61P37/02; C07D413/02
Foreign References:
| US20030171360A1 | 2003-09-11 | |||
| CN201910342107A | 2019-04-26 | |||
| US201962861857P | 2019-06-14 | |||
| CN107002037A | 2017-08-01 | |||
| US20180031217W | 2018-05-04 |
Other References:
RICCARDO RONDANIN, SIMONI DANIELE, MACCESI MARTINA, ROMAGNOLI ROMEO, GRIMAUDO STEFANIA, PIPITONE ROSARIA MARIA, MELI MARIA, CASCIO: "Effects of Pimozide Derivatives on pSTAT5 in K562 Cells", CHEMMEDCHEM, vol. 12, 28 June 2017 (2017-06-28), pages 1183 - 1190, XP055747424, ISSN: 1860-7179, DOI: 10.1002/cmdc.201700234
REBECCA POULAIN , DRAGOS HORVATH , BEATRICE BONNET , CHRISTIAN ECKHOFF , BEATRICE CHAPELAIN , MARIE-CHRISTINE BODINIER , BENOIT DE: "From Hit to Lead. Combining Two Complementary Methods for Focused Library Design. Application to μ Opiate Ligands", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 21, 31 October 2001 (2001-10-31), pages 3378 - 3390, XP002347154, ISSN: 0022-2623, DOI: :10.1021/jm010877o
DATABASE STN 4 March 2018 (2018-03-04), "CAS RN", XP009524045, retrieved from Registry
RONDANIN RICCARDO; SIMONI DANIELE; ROMAGNOLI ROMEO; BARUCHELLO RICCARDO; MARCHETTI PAOLO; COSTANTINI CRISTIANA; FOCHI SARA; PADRON: "Inhibition of Activated STAT5 in Bcr/Abl Expressing Leukemia Cells with New Pimozide Derivatives", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, 31 August 2014 (2014-08-31), pages 4568 - 4574, XP029053308, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2014.07.069
POULAIN, R. ET AL.: "From Hit to Lead. Analyzing Structure-Profile Relationships", J. MED. CHEM., vol. 44, no. 21, 11 September 2001 (2001-09-11), XP002395856
ANN RHEUM DIS, vol. 73, no. 3, March 2014 (2014-03-01), pages 529 - 35
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
CHINESE PHARMACOPOEIA, 2015
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2009
See also references of EP 3960736A4
REBECCA POULAIN , DRAGOS HORVATH , BEATRICE BONNET , CHRISTIAN ECKHOFF , BEATRICE CHAPELAIN , MARIE-CHRISTINE BODINIER , BENOIT DE: "From Hit to Lead. Combining Two Complementary Methods for Focused Library Design. Application to μ Opiate Ligands", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 21, 31 October 2001 (2001-10-31), pages 3378 - 3390, XP002347154, ISSN: 0022-2623, DOI: :10.1021/jm010877o
DATABASE STN 4 March 2018 (2018-03-04), "CAS RN", XP009524045, retrieved from Registry
RONDANIN RICCARDO; SIMONI DANIELE; ROMAGNOLI ROMEO; BARUCHELLO RICCARDO; MARCHETTI PAOLO; COSTANTINI CRISTIANA; FOCHI SARA; PADRON: "Inhibition of Activated STAT5 in Bcr/Abl Expressing Leukemia Cells with New Pimozide Derivatives", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, 31 August 2014 (2014-08-31), pages 4568 - 4574, XP029053308, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2014.07.069
POULAIN, R. ET AL.: "From Hit to Lead. Analyzing Structure-Profile Relationships", J. MED. CHEM., vol. 44, no. 21, 11 September 2001 (2001-09-11), XP002395856
ANN RHEUM DIS, vol. 73, no. 3, March 2014 (2014-03-01), pages 529 - 35
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
CHINESE PHARMACOPOEIA, 2015
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2009
See also references of EP 3960736A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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