HETEROCYCLIC COMPOUND AS A PROTEIN KINASE INHIBITOR

Title:

HETEROCYCLIC COMPOUND AS A PROTEIN KINASE INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2019/078619

Kind Code:

A1

Abstract:

The present invention provides a novel compound having a protein kinase inhibition activity, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. The compound, the stereoisomer thereof or the pharmaceutically acceptable salt thereof according to the present invention show a protein kinase inhibition activity, thus being effective in preventing or treating diseases related to protein kinase, such as cancer, autoimmune disease, neurological disease, metabolic disease, infection or the like.

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Inventors:

LEE HYUK WOO (KR)
JI MI KYUNG (KR)
KIM SEUNG CHAN (KR)
YU HA NA (KR)
JUNG SOO YEON (KR)
PARK JI-YEON (KR)
LEE YE-LIM (KR)
LEE HO-YOUL (KR)
KI SO YOUNG (KR)
KIM DONGKYU (KR)
KIM MYEONGJOONG (KR)

Application Number:

PCT/KR2018/012270

Publication Date:

April 25, 2019

Filing Date:

October 17, 2018

Export Citation:

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Assignee:

CJ HEALTHCARE CORP (KR)

International Classes:

C07D471/04; A61K31/437; A61K31/519; C07D487/04

Domestic Patent References:

WO2017087905A1	2017-05-26
WO2010068806A1	2010-06-17
WO2017098467A1	2017-06-15
WO2014170248A1	2014-10-23

Other References:

LUCAS, X. ET AL.: "4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading", ANGEW. CHEM. INT. ED., vol. 52, 2013, pages 14055 - 14059, XP055124264, DOI: doi:10.1002/anie.201307652
LACROIX, C. ET AL.: "Identification of Novel Smoothened Ligands Using Structure-Based Docking", PLOS ONE, vol. 11, no. 8, 4 August 2016 (2016-08-04), pages e0160365 - 20, XP055597316, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0160365
See also references of EP 3697787A4

Attorney, Agent or Firm:

AHN, So Young (KR)

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